Effects of [Norleucine²⁷]Growth Hormone-Releasing Hormone (GHRH) (1–29)-NH₂Administration on the Immune System of Aging Men and Women¹

Aging in humans is associated with the decline of functional activities of the GH-insulin-like growth factor I (IGF-I) axis and the immune system. Because lymphocytes express GH-IGF-I, as well as GHRH and their respective receptors, restoration of this axis in age-advanced individuals, by the administration of GHRH, may enhance immune cell function. This hypothesis was tested by a single blind randomized placebo-controlled trial of 5 months...