S. S. C. Yen
University of California, San Diego
Circadian rhythmInternal medicineEndocrinologyLuteal phaseChemistryFollicular phaseHypothalamusEstrogenPituitary glandLuteinizing hormoneGonadotropinGonadotropin-releasing hormoneMenstrual cycleProlactinFollicle-stimulating hormoneInsulinHormoneMedicinePulsatile flowBiology
195Publications
88H-index
17.4kCitations
Publications 185
Newest
#1A. J. MoralesH-Index: 2
#2Richard Haubrich (UCSD: University of California, San Diego)H-Index: 59
Last. S. S. C. YenH-Index: 88
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OBJECTIVE The biological role of the adrenal sex steroid precursors - DHEA and DHEA sulphate (DS) and their decline with ageing remains undefined. We observed previously that administration of a 50 daily dose of DHEA for 3 months to age-advanced men and women resulted in an elevation (10%) of serum levels of insulin-like growth factor-I (IGF-I) accompanied by improvement of self-reported physical and psychological well-being. These findings led us to assess the effect of a larger dose (100 mg) o...
371 CitationsSource
#1H. F. Erden (UCSD: University of California, San Diego)H-Index: 1
#2I. H. Zwain (UCSD: University of California, San Diego)H-Index: 2
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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Recently, we reported that the thecal compartment of the human ovary contains a CRF system replete with gene expression and protein for corticotropin-releasing factor (CRF), CRF-Receptor 1 (CRF-R1), and the blood-derived high affinity CRF-binding protein (CRF-BP). Granulosa cells are devoid of the CRF system. The parallel increases in intensity of CRF, CRF-R1, and 17α-hydroxylase messenger ribonucleic acid (mRNA) and proteins in thecal cells with follicular maturation suggest that the intraovari...
20 CitationsSource
#1Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
#2Celia E Dominguez (UCSD: University of California, San Diego)H-Index: 4
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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The development of functional hypothalamic amenorrhea (FHA) in weight-stable, nonathletic women has long been thought to be psychogenic in origin. This study was designed to gain insight into the possibility that nutritional deficits and compensatory endocrine-metabolic adaptations contribute to the development and maintenance of FHA of the psychogenic type. Nutritional intake, insulin sensitivity, and 24-h dynamics of insulin/glucose, cortisol, leptin, somatotropic, and LH axes were simultaneou...
165 CitationsSource
#1O. Khorram (UCSD: University of California, San Diego)H-Index: 1
#2M. Yeung (UCSD: University of California, San Diego)H-Index: 1
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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Aging in humans is associated with the decline of functional activities of the GH-insulin-like growth factor I (IGF-I) axis and the immune system. Because lymphocytes express GH-IGF-I, as well as GHRH and their respective receptors, restoration of this axis in age-advanced individuals, by the administration of GHRH, may enhance immune cell function. This hypothesis was tested by a single blind randomized placebo-controlled trial of 5 months duration, in which healthy elderly subjects (10 women, ...
34 CitationsSource
#1A. Arroyo (UCSD: University of California, San Diego)H-Index: 1
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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In recent years, there has been uncertainty concerning the association of inappropriate gonadotropin secretion (high LH and normal FSH) and the polycystic ovary syndrome (PCOS). In the present study, we ascertained the influence of body composition on LH pulsatile parameters in 33 PCOS and 32 normal cycling (NC) women across a wide range of body mass index (BMI, 19–42 kg/m2). Twenty four-hour pulsatile parameters for serum LH (10-min sampling) and pituitary gonadotropin responses to iv bolus GnR...
168 CitationsSource
#1H. Asakura (UCSD: University of California, San Diego)H-Index: 2
#2I. H. Zwain (UCSD: University of California, San Diego)H-Index: 2
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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Recently, the presence of immunoreactive corticotropin-releasing factor (IrCRF) in the thecal-stromal cells of the human ovary and the ability of CRF to suppress estrogen production by human granulosa cells in vitro have been reported. To understand the functional role of ovarian CRF requires characterization of the human ovarian CRF system, which includes CRF, type 1 CRF receptor (CRF-R1), and the high affinity CRF-binding protein (CRF-BP). Accordingly, we have examined the ovarian CRF system a...
45 CitationsSource
#1Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
#2Arlene J. Morales (UCSD: University of California, San Diego)H-Index: 18
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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Polycystic ovary syndrome (PCOS) is associated with chronic anovulation, hyperandrogenemia, insulin resistance (IR)/hyperinsulinemia, and a high incidence of obesity. Thus, PCOS serves as a useful model to assess the role of IR and chronic endogenous insulin excess on leptin levels. Thirty-three PCOS and 32 normally cycling (NC) women of similar body mass index (BMI) were studied. Insulin sensitivity (SI) was assessed by rapid ivGTT in a subset of 28 PCOS and 29 NC subjects; percent body fat was...
150 CitationsSource
#1A. Cagnacci (UCSD: University of California, San Diego)H-Index: 1
#2R. Soldani (UCSD: University of California, San Diego)H-Index: 1
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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Cagnacci A, Soldani R, Yen SSC. Melatonin enhances Cortisol levels in aged women: Reversible by estrogens. J. Pineal Res. 1997; 22:81–85. © Munksgaard, Copenhagen Abstract The administration of melatonin increases Cortisol levels in postmenopausal women. Aging and hypoestrogenism are believed to impair the regulation of the hypothalamo-pituitary-adrenal axis and may participate in the determination of this altered response. In this study the implications of hypoestrogenism were tested. Seven pos...
33 CitationsSource
#1A. Cagnacci (UCSD: University of California, San Diego)H-Index: 1
#2R. Soldani (UCSD: University of California, San Diego)H-Index: 1
Last. S. S. C. Yen (UCSD: University of California, San Diego)H-Index: 88
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We investigated whether the contemporaneous administration of melatonin can modify circadian phase shifts induced by bright light stimuli. After a baseline evaluation, 10 women were exposed for three consecutive nights to a 4-h bright light stimulus (>3,000 lx) initiated at the time of the estimated core body temperature (BT(c)) nadir. Along with light, each woman orally received, randomly and in a double-blind fashion, placebo (n = 5) or melatonin (n = 5; 1 mg 30 min before and 0.75 mg 120 min ...
26 CitationsSource
#1Angelo CagnacciH-Index: 35
#2Fabio FacchinettiH-Index: 73
Last. Annibale VolpeH-Index: 60
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