β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids
Abstract
Cancer cells form three-dimensional (3D) multicellular aggregates (or spheroids) under non-adherent culture conditions. In ovarian cancer (OC), spheroids serve as a vehicle for cancer cell dissemination in the peritoneal cavity, protecting cells from environmental stress-induced anoikis. To identify new targetable molecules in OC spheroids, we investigated gene expression profiles and networks upregulated in 3D vs traditional monolayer culture...
Paper Details
Title
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids
Published Date
Jun 23, 2014
Journal
Volume
34
Issue
18
Pages
2297 - 2308
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