Double‐blind, randomized trial of roxatidine 150 mg in the early evening versus bedtime administration in the short‐term treatment of duodenal ulcer

To compare the efficacy and tolerability of early evening (19.00-21.00 hours) vs. bedtime (22.00-00.00 hours) oral administration of roxatidine 150 mg in the short-term treatment of active duodenal ulcer.The trial was randomized, double-blind and double-dummy, with parallel groups. A total of 276 patients were recruited and randomly assigned either to roxatidine in the early evening (n = 139) or roxatidine at bedtime (n = 137).After 4 weeks, 78%...