Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents a potentially powerful technology. Using prostate cancer as a model, we report docetaxel (Dtxl)-encapsulated nanoparticles formulated with biocompatible and biodegradable poly( d , l -lactic- co -glycolic acid)- block -poly(ethylene glycol) (PLGA- b -PEG) copolymer and surface functionalized with the A10 2′-fluoropyrimidine RNA aptamers that...