Robert Langer
Massachusetts Institute of Technology
BiophysicsInternal medicineBiomedical engineeringNanoparticleControlled releaseNanotechnologyChemistryPolymer chemistryMaterials scienceIn vivoDrug deliveryChemical engineeringBiodegradable polymerTissue engineeringPolymerBiochemistryMedicineBiologyCell biologyPharmacology
2,083Publications
296H-index
252kCitations
Publications 1993
Newest
#1David A. Edwards (Harvard University)H-Index: 28
#2Jonathan SalzmanH-Index: 3
Last. Robert Langer (MIT: Massachusetts Institute of Technology)H-Index: 296
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Stohner (1) mistakenly identifies the correlation drawn in our recent article (2) between exhaled aerosol and body mass index (BMI)-age as based on a figure legend to which the article does not itself allude. In our article (2), we establish that those individuals with high BMI-years (above 650) exhaled significantly more aerosol than those with low BMI-years (below 650). Those with BMI-years less than 650 exhaled a mean of 29.81 ± 9.83, and those with BMI-years above 650 exhaled a mean … [↵][1]...
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#1Joshua C. Doloff (MIT: Massachusetts Institute of Technology)H-Index: 21
#1Joshua C. Dolo (MIT: Massachusetts Institute of Technology)
Last. Daniel G. AndersonH-Index: 119
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#1Joshua C. DoloffH-Index: 21
#2Omid VeisehH-Index: 42
Last. Samira Aghlara-Fotovat (Rice University)H-Index: 1
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Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0–90 μm) placed in the mammary fat pads of mice or rabbits, respectively, we show that ...
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#1Pooyan Makvandi (IIT: Istituto Italiano di Tecnologia)H-Index: 20
#2Rezvan Jamaledin (University of Naples Federico II)H-Index: 8
Last. Robert Langer (MIT: Massachusetts Institute of Technology)H-Index: 296
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Abstract Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action towar...
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#1Robert Langer (UCSD: University of California, San Diego)H-Index: 296
Successful aging includes good health and low levels of disability. To that end, primary prevention is far better than managing subsequent organ damage. When medication is needed to prevent or mana...
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#1Daniel Reker (MIT: Massachusetts Institute of Technology)H-Index: 19
#2Yulia Rybakova (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Giovanni Traverso (MIT: Massachusetts Institute of Technology)H-Index: 30
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Nanoformulations of therapeutic drugs are transforming our ability to effectively deliver and treat a myriad of conditions. Often, however, they are complex to produce and exhibit low drug loading, except for nanoparticles formed via co-assembly of drugs and small molecular dyes, which display drug-loading capacities of up to 95%. There is currently no understanding of which of the millions of small-molecule combinations can result in the formation of these nanoparticles. Here we report the inte...
1 CitationsSource
#1Ameya R. Kirtane (MIT: Massachusetts Institute of Technology)H-Index: 14
#2Malvika Verma (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Giovanni Traverso (MIT: Massachusetts Institute of Technology)H-Index: 30
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Infectious diseases are a major driver of morbidity and mortality globally. Treatment of malaria, tuberculosis and human immunodeficiency virus infection are particularly challenging, as indicated by the ongoing transmission and high mortality associated with these diseases. The formulation of new and existing drugs in nano-sized carriers promises to overcome several challenges associated with the treatment of these diseases, including low on-target bioavailability, sub-therapeutic drug accumula...
1 CitationsSource
#1David A. Edwards (Harvard University)H-Index: 28
#2Dennis A. Ausiello (Harvard University)H-Index: 60
Last. Chad J. Roy (Tulane University)H-Index: 143
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COVID-19 transmits by droplets generated from surfaces of airway mucus during processes of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. We studied respiratory droplet generation and exhalation in human and nonhuman primate subjects with and without COVID-19 infection to explore whether SARS-CoV-2 infection, and other changes in physiological state, translate into observable evolution of numbers and sizes of exhaled respiratory droplets ...
10 CitationsSource
#1William McLeanH-Index: 9
Last. Carl LebelH-Index: 10
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OBJECTIVES There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been shown to regenerate mammalian cochlear hair cells ex vivo. The objectives were to characterize the cochlear pharmacokinetic profile of CV in guinea pigs, then measure FX-322 in human perilymph samples, and finally assess safety and audiometric effects of FX-322 in humans with chronic SNHL. STUDY DESIGNS Middle ear residence, coch...
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#1Michael J. Mitchell (UPenn: University of Pennsylvania)H-Index: 56
#2Margaret M. Billingsley (UPenn: University of Pennsylvania)H-Index: 7
Last. Robert Langer (MIT: Massachusetts Institute of Technology)H-Index: 296
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In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental and cellular — that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficac...
46 CitationsSource