Original paper
The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography
Abstract
Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear relationship between and for substances with known lipophilicity was found. The lipophilicity of purine derivatives was worked out from the...
Paper Details
Title
The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography
Published Date
Jan 1, 2013
Journal
Volume
2013
Pages
1 - 4
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Notes
History