The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography

Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear relationship between and for substances with known lipophilicity was found. The lipophilicity of purine derivatives was worked out from the...