Original paper
Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells
Abstract
The prostate epithelial lineage hierarchy remains inadequately defined. Recent lineage-tracing studies have implied the existence of prostate luminal epithelial progenitors with extensive regenerative capacity. However, this capacity has not been demonstrated in prostate stem cell activity assays, probably owing to the strong susceptibility of luminal progenitors to anoikis. Here we show that constitutive expression of Notch1 intracellular...
Paper Details
Title
Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells
Published Date
Jul 22, 2014
Journal
Volume
5
Issue
1
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Notes
History