Original paper
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance
Abstract
Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed. In 40 IGT subjects and 63 sex-, age-, and weight-matched controls with normal glucose tolerance (NGT), we measured (i) indices of insulin sensitivity of fasting glucose production (by tracer glucose) and glucose disposal (M value on a 240 pmol·min–1·m–2...
Paper Details
Title
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance
Published Date
Sep 1, 2003
Journal
Volume
46
Issue
9
Pages
1211 - 1219
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Notes
History