Ralph A. DeFronzo
University of Texas Health Science Center at San Antonio
EndocrinologyCarbohydrate metabolismChemistryType 2 diabetesInsulin resistanceGlucose uptakeBasal (medicine)PioglitazoneGlucagonGlucose clamp techniqueInsulinMetforminImpaired glucose toleranceGlucose tolerance testHyperinsulinemiaType 2 Diabetes MellitusDiabetes mellitusMetabolismMedicineBiology
Publications 850
#1Georgios Ponirakis (Qatar Foundation)H-Index: 22
#2Muhammad A Abdul-ghani (Hamad Medical Corporation)H-Index: 2
Last. Rayaz A. MalikH-Index: 78
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AIMS/INTRODUCTION This study aimed to investigate whether insulin resistance (IR) in subjects with T2D undergoing intensive glycemic control determines the extent of improvement in neuropathy. MATERIALS AND METHODS This is an exploratory sub-study of an open-label, randomized controlled trial of subjects with poorly controlled T2D treated with exenatide and pioglitazone or insulin to achieve an HbA1c <7.0% (<53 mmol/mol). Baseline IR was defined using HOMA-IR and change in neuropathy was assesse...
#1S Abdelgani (University of Texas Health Science Center at San Antonio)
#1Siham Abdelgani (University of Texas Health Science Center at San Antonio)
Last. Muhammad A. Abdul-Ghani (University of Texas Health Science Center at San Antonio)H-Index: 53
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Aim To identify predictors of response to glucose lowering therapy in patients with new onset diabetes and very high HbA1c (>10%). Research design and methods The study included EDICT participants with initial HbA1c >10% (N = 104). All subjects received a 75-g OGTT before initiation of therapy, and then were randomized to receive: (i) initial Triple Therapy with metformin, pioglitazone, and exenatide versus (ii) stepwise Conventional Therapy with metformin followed by glipizide and then glargine...
#1Amalia Gastaldelli (University of Texas Health Science Center at San Antonio)H-Index: 85
#2Ralph A. DeFronzo (University of Texas Health Science Center at San Antonio)H-Index: 179
Last. Marzieh Salehi (University of Texas Health Science Center at San Antonio)H-Index: 18
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We read with interest the review by Piccinini and Bergman (1) that 1 ) argues for superiority of the Polidori-Bergman model or peripheral-portal infusion technique to estimate the metabolic clearance rate of insulin (MCR-I) over other methods, and 2 ) hypothesizes that reduced MCR-I causes type 2 diabetes (T2D). Obviously, the peripheral-portal infusion approach is not feasible in humans. The Polidori-Bergman model allows one to estimate the MCR-I contribution of the liver and peripheral tissues...
1 CitationsSource
#1Vasudha AhujaH-Index: 1
#2Pasi AronenH-Index: 10
Last. Tiinamaija TuomiH-Index: 97
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#1Henri Honka (University of Texas at Austin)
#2Carolina Solis-Herrera (University of Texas at Austin)H-Index: 11
Last. Ralph A. DeFronzo (University of Texas at Austin)H-Index: 179
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Abstract The mechanisms responsible for the positive and unexpected cardiovascular effects of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes remain to be defined. It is likely that some of the beneficial cardiac effects of these antidiabetic drugs are mediated, in part, by altered myocardial metabolism. Common cardiometabolic disorders, including the metabolic (insulin resistance) syndrome and type 2 diabetes, are associat...
#1Eithan Kotkowski (University of Texas Health Science Center at San Antonio)H-Index: 3
#2Larry R. Price (Texas State University)H-Index: 20
Last. Peter T. Fox (University of Texas Health Science Center at San Antonio)H-Index: 142
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The posterior cerebellum is the most significantly compromised brain structure in individuals with metabolic syndrome (MetS) (Hum Brain Mapp 40(12):3575–3588, 2019). In light of this, we hypothesized that cognitive decline reported in patients with MetS is likely related to posterior cerebellar atrophy. In this study, we performed a post hoc analyses using T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) in the form of voxel-wise tract-based spatial statistics (TBSS),...
#1Vasudha Ahuja (UH: University of Helsinki)H-Index: 1
#2Pasi Aronen (UH: University of Helsinki)H-Index: 10
Last. Tiinamaija Tuomi (UH: University of Helsinki)H-Index: 97
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Objective One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. Research design and methods We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and 2,705 newly detected cases of diabetes based on 2-h PG during OGTT. We excluded cases identified only...
1 CitationsSource
#2Ralph A. DeFronzoH-Index: 179
#1Muhammad A. Abdul-Ghani (University of Texas Health Science Center at San Antonio)H-Index: 53
#2Ralph A. DeFronzo (University of Texas Health Science Center at San Antonio)H-Index: 179
#1Jiyoon RyuH-Index: 6
#2Jason T. HadleyH-Index: 1
Last. Lily Q. DongH-Index: 42
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Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in insulin target tissues including liver. While the insulin-sensitizing function of adiponectin has been extensively investigated, the precise mechanism by which adiponectin alleviates diet-induced hepatic inflammation remains elusive. Here, we report that hepatocyte-specific knockout (KO) of the adaptor protein APPL2 enhanced adiponectin sensitivity and prevented mice from developing high-fat diet–induced i...