Amalia Gastaldelli
National Research Council
Internal medicineEndocrinologyCarbohydrate metabolismAdipose tissueChemistrySteatosisType 2 diabetesInsulin resistancePostprandialGlucagonFatty liverDiseaseInsulinGlucose tolerance testPopulationObesityDiabetes mellitusMedicineBiologyGastroenterology
Publications 429
#1Dario Tuccinardi (Università Campus Bio-Medico)H-Index: 15
#2Antonio Di Mauro (Università Campus Bio-Medico)H-Index: 2
Last. Andreea Soare (Università Campus Bio-Medico)H-Index: 6
view all 18 authors...
AIMS To investigate if extra virgin olive oil (EVOO) or palm oil enriched chocolate spreads consumption leads to different results in terms of plasma ceramides concentration, glucose and lipid metabolism, inflammatory markers and appetite regulation in young healthy subjects. METHODS In a 2-week, double-blind, cross-over, randomized controlled trial, 20 healthy, normal-weight subjects with a mean age of 24.2 years(SD: 1.2), consumed chocolate spread snacks (73% of energy [%E] from fat, 20% from ...
#1Roberto BizzottoH-Index: 7
#2Domenico Tricò (UniPi: University of Pisa)H-Index: 13
Last. Andrea MariH-Index: 31
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OBJECTIVE null Endogenous insulin clearance (EIC) is physiologically reduced at increasing insulin secretion rate (ISR). Computing EIC at the prevailing ISR does not distinguish the effects of hypersecretion from those of other mechanisms of glucose homeostasis. We aimed to measure EIC in standardized ISR conditions (i.e., at fixed ISR levels) and to analyze its associations with relevant physiologic factors. null RESEARCH DESIGN AND METHODS null We estimated standardized EIC (EICISR) by mathema...
#1Giuseppe Della Pepa (University of Naples Federico II)H-Index: 10
#2Marco Russo (UNISI: University of Siena)
Last. Angela A. Rivellese (University of Naples Federico II)H-Index: 51
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Abstract null null Aims null Non-Alcoholic Fatty Liver Disease (NAFLD) and type 2 diabetes (T2D) share pathophysiological mechanisms and possible therapeutic strategies. We evaluated the effects of 1-year treatment with pioglitazone or sulphonylureas on indirect indices of NAFLD in people with T2D and the role of insulin-resistance and glucotoxicity in determining these effects. null null null Methods null Patients with T2D (n = 195) aged 50–75 years, poorly controlled with metformin 2 g/day, we...
#1Amalia Gastaldelli (National Research Council)H-Index: 85
#2Silvia Sabatini (UNISI: University of Siena)
Last. Stephen A. Harrison (Pinnacle Financial Partners)H-Index: 52
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BACKGROUND&AIMS PPAR-γ agonists decrease hepatic/visceral fat (VF) and improve necroinflammation despite subcutaneous (SC) fat weight-gain. Understanding the impact of changes in VF, VF-to-SC distribution (VF/SC) and adiponectin levels in relation to histological improvement after weight-loss or pioglitazone is relevant as novel PPAR-γ agonists are being developed for treating NASH. METHODS Fifty-five patients with NASH received a -500 kcal/day hypocaloric diet and were randomized (double-blind)...
1 CitationsSource
#1Charalampia Amerikanou (HUA: Harokopio University)H-Index: 5
#2Efstathia Papada (HUA: Harokopio University)H-Index: 7
Last. Natasa Milic (University of Novi Sad)H-Index: 21
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Abstract null null Mastiha is a natural nutritional supplement with known anti-inflammatory properties. Non-alcoholic fatty liver disease (NAFLD) and Inflammatory bowel disease (IBD) are immune mediated inflammatory diseases that share common pathophysiological features. Mastiha has shown beneficial effects in both diseases. MicroRNAs have emerged as key regulators of inflammation and their modulation by phytochemicals have been extensively studied over the last years. Therefore, the aim of this...
#1Henri HonkaH-Index: 8
#2Maria RayasH-Index: 5
Last. Marzieh SalehiH-Index: 19
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#1Maria RayasH-Index: 5
#2Henri HonkaH-Index: 8
Last. Marzieh SalehiH-Index: 19
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#1Giulia Angelini (UCSC: Catholic University of the Sacred Heart)H-Index: 6
#2Serenella SalinariH-Index: 47
Last. Geltrude MingroneH-Index: 71
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Objective To assess the role of jejunum in insulin resistance in humans and in experimental animals. Design Twenty-four subjects undergoing biliopancreatic diversion (BPD) or Roux-en-Y gastric bypass (RYGB) were enrolled. Insulin sensitivity was measured at baseline and at 1 week after surgery using oral glucose minimal model. We excluded the jejunum from intestinal continuity in pigs and created a jejunal loop with its vascular and nerve supply intact accessible from two cutaneous stomas, and r...
4 CitationsSource
#1Melania GagginiH-Index: 18
#2Cristina VassalleH-Index: 27
Last. Alessandro PingitoreH-Index: 40
view all 10 authors...
#1Stavroula Kanoni (QMUL: Queen Mary University of London)H-Index: 60
#2Satish KumarH-Index: 14
Last. Sophie Visvikis-SiestH-Index: 34
view all 29 authors...
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic background and the environment. Mastiha is a natural nutritional supplement known to possess antioxidant and anti-inflammatory properties. This study investigated how a 6-month Mastiha supplementation (2.1 g/day) could impact the antioxidant and inflammato...