Antibacterial Efficacy of Inhalable Antibiotic-Encapsulated Biodegradable Polymeric Nanoparticles Against <I>E. coli</I> Biofilm Cells

Biofilm is a sessile community of bacterial cells enclosed by a self-secreted extracellular polymeric matrix that exhibit a high recalcitrance towards antibiotics. Inhaled antibiotic nanoparticles with a sustained release capability have emerged as one of the most promising anti-biofilm formulations in the fight against respiratory biofilm infections attributed to their ability to penetrate the biofilm sputum. The present work examines the...