PET/MR imaging of bone lesions – implications for PET quantification from imperfect attenuation correction

Accurate attenuation correction (AC) is essential for quantitative analysis of PET tracer distribution. In MR, the lack of cortical bone signal makes bone segmentation difficult and may require implementation of special sequences. The purpose of this study was to evaluate the need for accurate bone segmentation in MR-based AC for whole-body PET/MR imaging.In 22 patients undergoing sequential PET/CT and 3-T MR imaging, modified CT AC maps were...