European Journal of Nuclear Medicine and Molecular Imaging
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#1Pascalle Mossel (UMCG: University Medical Center Groningen)
#2Lara Garcia Varela (UMCG: University Medical Center Groningen)H-Index: 2
Last. Gert Luurtsema (UMCG: University Medical Center Groningen)H-Index: 27
view all 16 authors...
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#1Nicolas AideH-Index: 27
#2Charline Lasnon (French Institute of Health and Medical Research)H-Index: 12
Last. Daniel R. McGowan (Churchill Hospital)H-Index: 13
view all 11 authors...
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#1Pim P. van de Donk (UMCG: University Medical Center Groningen)H-Index: 1
#2Thijs T Wind (UMCG: University Medical Center Groningen)H-Index: 4
Last. Geke A.P. Hospers (UMCG: University Medical Center Groningen)H-Index: 37
view all 10 authors...
PURPOSE Immune checkpoint inhibitors can induce a T cell-mediated anti-tumor immune response in patients with melanoma. Visualizing T cell activity using positron emission tomography (PET) might allow early insight into treatment efficacy. Activated tumor-infiltrating T cells express the high-affinity interleukin-2 receptor (IL-2R). Therefore, we performed a pilot study, using fluorine-18-labeled IL-2 ([18F]FB-IL2 PET), to evaluate whether a treatment-induced immune response can be detected. MET...
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#1Susan Bengs (UZH: University of Zurich)H-Index: 9
#2Ahmed Haider (UZH: University of Zurich)H-Index: 9
Last. Catherine Gebhard (UZH: University of Zurich)H-Index: 22
view all 19 authors...
Perivascular fat attenuation index (FAI) has emerged as a novel coronary computed tomography angiography (CCTA)–based biomarker predicting cardiovascular outcomes by capturing early coronary inflammation. It is currently unknown whether FAI adds prognostic value beyond that provided by single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) and CCTA findings including coronary artery calcium scoring (CACS). A total of 492 patients (mean age 62.5 ± 10.8 years) underwen...
1 CitationsSource
#1Lena Mittlmeier (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Marcus Unterrainer (LMU: Ludwig Maximilian University of Munich)H-Index: 15
Last. Michael Staehler (LMU: Ludwig Maximilian University of Munich)H-Index: 56
view all 13 authors...
Introduction Tyrosine kinase (TKI) and checkpoint inhibitors (CI) prolonged overall survival in metastatic renal cell carcinoma (mRCC). Early prediction of treatment response is highly desirable for the individualization of patient management and improvement of therapeutic outcome; however, serum biochemistry is unable to predict therapeutic efficacy. Therefore, we compared 18F-PSMA-1007 PET imaging for response assessment in mRCC patients undergoing TKI or CI therapy compared to CT-based respon...
1 CitationsSource
#1Loïc DjailebH-Index: 4
#2Alexandre Seiller (French Institute of Health and Medical Research)H-Index: 1
Last. Gilles Barone-Rochette (French Institute of Health and Medical Research)H-Index: 14
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PURPOSE Risk stratification of patients with type 2 diabetes mellitus (T2D) remains suboptimal. We hypothesized that myocardial perfusion entropy (MPE) quantified from SPECT myocardial perfusion images may provide incremental prognostic value in T2D patients independently from myocardial ischemia. METHODS T2D patients with very high and high cardiovascular risk were prospectively included (n = 166, 65 ± 12 years). Stress perfusion defect was quantified by visual evaluation of SPECT MPI. SPECT MP...
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#1Laura Kuebler (University of Tübingen)H-Index: 3
#2Sabrina Buss (University of Tübingen)H-Index: 1
Last. Kristina Herfert (University of Tübingen)H-Index: 4
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Purpose Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on anle138b, a compound shown to have therapeutic activity in animal models of neurodegenerative diseases. Methods Specificity and selectivity of [3H]MODAG-001 were tested in in vitro b...
1 CitationsSource
#1K. Van der Geest (UMCG: University Medical Center Groningen)H-Index: 2
#2Giorgio TregliaH-Index: 47
Last. O. Gheysens (Cliniques Universitaires Saint-Luc)H-Index: 2
view all 7 authors...
PURPOSE Polymyalgia rheumatica (PMR) can be difficult to diagnose. Whole-body [18F]FDG-PET/CT allows for a comprehensive evaluation of all relevant articular and extra-articular structures affected by PMR. We aimed to summarize current evidence on the diagnostic value of [18F]FDG-PET/CT for a diagnosis of PMR. METHODS PubMed/MEDLINE and the Cochrane Library database were searched from inception through May 31, 2020. Studies containing patients with PMR who underwent [18F]FDG-PET/CT were included...
2 CitationsSource
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Top fields of study
Radiology
Pathology
Positron emission tomography
Nuclear medicine
Medicine