Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Published on Feb 25, 2012in Human Genetics4.132
· DOI :10.1007/S00439-012-1144-8
H. Dean Hosgood33
Estimated H-index: 33
(NIH: National Institutes of Health),
Wen Chang Wang15
Estimated H-index: 15
(NHRI: National Health Research Institutes)
+ 81 AuthorsChen Wu59
Estimated H-index: 59
(Peking Union Medical College)
Sources
Abstract
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10−12); however, this association did not achieve genome-wide significance (p ≤ 10−7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10−8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74–0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67–0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.
📖 Papers frequently viewed together
14 Authors (Xifeng Wu)
49 Authors (James McKay, ..., Jolanta Lissowska)
20 Authors (Xifeng Wu, Xiangjun Gu)
References35
Newest
#1Biyun Qian (Tianjin Medical University)H-Index: 9
#2Huan Zhang (Tianjin Medical University)H-Index: 1
Last. Kexin Chen (Tianjin Medical University)H-Index: 34
view all 6 authors...
Abstract DNA repair function is believed to play an important role in cancer development and to be affected by genetic polymorphisms. Numerous epidemiological studies have examined the associations between single nucleotide polymorphisms (SNPs) in the DNA repair genes and lung cancer risk, but the results are inconsistent. The aim of this study was to investigate the associations of several SNPs in the DNA repair pathways and risk of non-small cell lung cancer (NSCLC) in a Chinese population. Th...
Source
#1Zhibin Hu (Nanjing Medical University)H-Index: 82
#2Chen Wu (Peking Union Medical College)H-Index: 59
Last. Wen Tan (Peking Union Medical College)H-Index: 72
view all 45 authors...
Hongbing Shen and colleagues report a genome-wide association study for lung cancer in individuals of Han Chinese ancestry. The authors identify two new lung cancer susceptibility loci.
Source
#1Gerry Melino (Medical Research Council)H-Index: 108
p53 mutations, occurring in two-thirds of all human cancers, confer a gain of function phenotype, including the ability to form metastasis, the determining feature in the prognosis of most human cancer. This effect seems mediated at least partially by its ability to physically interact with p63, thus affecting a cell invasion pathway, and accordingly, p63 is deregulated in human cancers. In addition, p63, as an ‘epithelial organizer', directly impinges on epidermal mesenchimal transition, stemne...
Source
#1H. Dean Hosgood (UMD: University of Maryland, College Park)H-Index: 33
#2Hu Wei (UMD: University of Maryland, College Park)H-Index: 5
Last. Qing Lan (UMD: University of Maryland, College Park)H-Index: 2
view all 8 authors...
Background Emissions from household coal combustion associated with cooking and heating are an important public health issue, particularly in China where hundreds of millions of people are exposed. Although coal emissions are a known human carcinogen, there is still uncertainty about the level of risk for lung and other cancers. Methods We performed a meta-analysis on 25 case–control studies (10 142 cases and 13 416 controls) to summarize the association between household coal use and lung cance...
Source
#1Daiki Miki (UTokyo: University of Tokyo)H-Index: 1
#2Michiaki KuboH-Index: 121
Last. Yataro Daigo (UTokyo: University of Tokyo)H-Index: 73
view all 17 authors...
Yataro Daigo and colleagues report a genome-wide association study for lung adenocarcinoma in Japanese and Korean populations, identifying a susceptibility locus at TP63.
Source
#1Chao A. Hsiung (NHRI: National Health Research Institutes)H-Index: 62
#2Qing Lan (NIH: National Institutes of Health)H-Index: 84
Last. Wei Zheng (Vandy: Vanderbilt University)H-Index: 174
view all 80 authors...
Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10 27 or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide associ...
Source
#1Li Tang (NUS: National University of Singapore)H-Index: 1
#2Wei-Yen LimH-Index: 36
Last. Adeline SeowH-Index: 51
view all 8 authors...
BackgroundEpidemiologic data suggest that Chinese women have a high incidence of lung cancer in relation to their smoking prevalence. In addition to active tobacco smoke exposure, other sources of ...
Source
#1Zhihua Yin (PRC: China Medical University (PRC))H-Index: 23
#2Meng Su (PRC: China Medical University (PRC))H-Index: 4
Last. Baosen Zhou (PRC: China Medical University (PRC))H-Index: 31
view all 7 authors...
Background Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer. This study aimed to investigate the association between the ERCC2 751, 312 and ERCC1 118 polymorphisms and the risk of lung adenocarcinoma in Chinese non-smoking females.
Source
#1Maria Teresa Landi (NIH: National Institutes of Health)H-Index: 75
#2Nilanjan Chatterjee (NIH: National Institutes of Health)H-Index: 90
Last. Neil E. Caporaso (NIH: National Institutes of Health)H-Index: 110
view all 67 authors...
Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additiona...
Source
#1Chen Wu (Peking Union Medical College)H-Index: 59
#2Zhibin HuH-Index: 82
Last. Hongbing ShenH-Index: 82
view all 14 authors...
Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asians, arguing against any of these being causative variants. This study sought to identify other variants on 15q25 associated with lung cancer susceptibility in Chinese. Two-stage case-control studies were conducted in subjects derived from both Northern and Southern China. The firs...
Source
Cited By31
Newest
#1Jieyi LongH-Index: 2
#2Tingting LongH-Index: 1
Last. Liming ChengH-Index: 15
view all 7 authors...
Source
#1Song Xu (Tianjin Medical University General Hospital)H-Index: 7
#2Yanye Wang (Tianjin Medical University General Hospital)H-Index: 2
Last. Jun Chen (Tianjin Medical University General Hospital)H-Index: 23
view all 9 authors...
BACKGROUND The prognostic factors for early-stage nonsmall cell lung cancers (NSCLCs) are not well defined. This study aimed to investigate the effect of highly frequent mutations on the outcomes patients with early-stage NSCLC, particularly those with surgically resected stage I disease. METHODS The Cancer Genome Atlas (TCGA) datasets for Lung Adenocarcinoma (LUAD), Lung Squamous Cell Carcinoma (LUSC), and Pan-Lung Cancer (PLC) were accessed via cBioportal and searched to identify patients with...
Source
#1Stephen MilneH-Index: 10
#2Xuan Li (UBC: University of British Columbia)H-Index: 9
Last. Ma'en Obeidat (UBC: University of British Columbia)H-Index: 25
view all 12 authors...
Background The anti-inflammatory pneumoprotein club cell secretory protein-16 (CC-16) is associated with the clinical expression of chronic obstructive pulmonary disease (COPD). We aimed to determine if there is a causal effect of serum CC-16 level on the risk of having COPD and/or its progression using Mendelian randomisation (MR) analysis. Methods We performed a genome-wide association meta-analysis for serum CC-16 in two COPD cohorts (Lung Health Study (LHS), n=3850 and ECLIPSE, n=1702). We t...
Source
#1Seung Soo Yoo (Kyungpook National University Hospital)H-Index: 16
#2Hyo-Gyoung Kang (KNU: Kyungpook National University)H-Index: 13
Last. Jae Yong ParkH-Index: 62
view all 13 authors...
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results: Two polymorp...
Source
#1Stephen Milne (UBC: University of British Columbia)H-Index: 10
#2Xuan Li (UBC: University of British Columbia)H-Index: 9
Last. Ma'en Obeidat (UBC: University of British Columbia)H-Index: 25
view all 12 authors...
Background: There are currently no robust biomarkers of chronic obstructive pulmonary disease (COPD) risk or progression. Club cell secretory protein-16 (CC-16) is associated with the clinical expression of COPD. We aimed to determine if there is a causal effect of serum CC-16 level on COPD risk and/or progression using Mendelian randomisation (MR) analysis. Methods: We performed a genome-wide association meta-analysis for serum CC-16 in two COPD cohorts (Lung Health Study [LHS], n=3,850 and ECL...
Source
#1Li-Hsin Chien (NHRI: National Health Research Institutes)H-Index: 5
#2Chung-Hsing Chen (NHRI: National Health Research Institutes)H-Index: 6
Last. Chao A. Hsiung (NHRI: National Health Research Institutes)H-Index: 62
view all 28 authors...
Background: High disease burden suggests the desirability to identify high-risk Asian never-smoking females (NSFs) who may benefit from low-dose computed tomography (LDCT) screening. In North America, one is eligible for LDCT screening if one satisfies the U.S. Preventive Services Task Force (USPSTF) criteria or has model-estimated six-year risk >0.0151. According to two US reports, only 36.6% female lung cancer patients met the USPSTF criteria, while 38% of the ever-smokers aged 55-74 met the U...
Source
Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). However, no data are available from any Indian population on the association of this variant with NSCLC. Using TaqMan genotyping chemistry, we conducted a case–control study involving 190 NSCLC cases and 400 ethnic, age-matched controls to explore the association of rs10937405 genetic v...
Source
#1Yang WenH-Index: 11
Last. Hongbing ShenH-Index: 82
view all 14 authors...
: Genome-wide association studies (GWASs) have consistently identified chromosome 3q28 as a lung cancer susceptibility region. To further characterize the potential genetic mechanism of the variants in this region, we conducted a fine-mapping study on chromosome 3q28 region. We performed a target resequencing in 200 lung cancer cases and 300 controls in the screening and followed by validation in multi-ethnic lung cancer GWASs with 12,843 cases and 12,639 controls. For our identified novel varia...
Source
#3Yannan Yuan (PKU: Peking University)H-Index: 7
#4Shuo Liu (PKU: Peking University)H-Index: 6
Last. Aiguo Ren (PKU: Peking University)H-Index: 32
view all 8 authors...
Objective: The objective of this study was to characterize secular trends in the sex-specific, age-standardized incidence of lung cancer by histological type in Beijing, China, from 2000 to 2016 based on data from a population-based cancer registry. Methods: Data on the incidence of cancer from 2000 to 2016 were obtained from the Beijing Cancer Registry. We examined trends in the sex-specific, age-standardized incidence of lung cancer by histological type using a Joinpoint regression model. Resu...
Source
#1Caiyang Liu (CQMU: Chongqing Medical University)H-Index: 3
#2Huijie Cui (Third Military Medical University)H-Index: 4
Last. Huanwen Chen (CQMU: Chongqing Medical University)H-Index: 5
view all 9 authors...
Abstract A growing number of studies investigating the association between Single Nucleotide Polymorphisms (SNPs) and lung cancer risk have been published since over a decade ago. An updated integrative assessment on the credibility and strength of the associations is required. We searched PubMed, Medline, and Web of Science on or before August 29th, 2016. A total of 198 articles were deemed eligible for inclusion, which addressed the associations between 108 variants and lung cancer. Among the ...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.