Role of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma

Summary Background Adhesion molecules such as intercellular adhesion molecule‐1 (ICAM‐1) are thought to contribute to the airway inflammation and airway hyper‐responsiveness (AHR) of allergic asthma. Some differences from allergic asthma have been noted, including airway neutrophilia, and the involvement of ICAM‐1 in toluene diisocyanate (TDI) asthma is currently unclear. Objective We utilized mice lacking ICAM‐1 expression (ICAM‐1 −/− ) to...