Shigeharu Myou
Kanazawa University
HistamineInternal medicineEndocrinologyChemistryImmunologyAsthmaBronchial hyperresponsivenessAntagonistInhalationEosinophilAcetaldehydeBronchoalveolar lavageGuinea pigCapsaicinBronchoconstrictionMethacholineCough reflexAnesthesiaMedicinePharmacology
120Publications
24H-index
1,765Citations
Publications 120
Newest
#1Yoshihisa IshiuraH-Index: 17
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shigeharu Myou (Kanazawa University)H-Index: 24
view all 7 authors...
Background - "Atopic cough" is a new clinical entity that presents with isolated chronic bronchodilator-resistant cough accepted in the Japanese Respiratory Society Guidelines for Management of Cough. The essential features are eosinophilic tracheobronchitis, increased cough reflex sensitivity and an atopic constitution. It has been suggested that activated helper T lymphocytes and the cytokines which are produced by these cells are involved in the pathogenesis, but the relationship between help...
6 CitationsSource
#1Toshiyuki KitaH-Index: 15
#2Masaki FujimuraH-Index: 53
Last. Shinji NakaoH-Index: 59
view all 6 authors...
#1Toshiyuki Kita (St. Marianna University School of Medicine)H-Index: 15
#2Masaki FujimuraH-Index: 53
Last. Shinji NakaoH-Index: 59
view all 9 authors...
BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the relationship between the wall structure assessed by using endobronchial ultrasonography (EBUS) and bronchial hyperresponsiveness in patients with asthma. METHODS: Twenty-four patients with stable asthma and 11 individuals without asthma were studied. EBUS was performed with a radial 20-MHz ultrasonic probe inserted into the intermediate bronchus undergoing flexible bronchoscopy to assess the airway wall structure. The percen...
5 CitationsSource
#1Yoshihisa IshiuraH-Index: 17
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shigeharu Myou (Kanazawa University)H-Index: 24
view all 5 authors...
Background Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial ...
8 CitationsSource
#1Toshiyuki KitaH-Index: 15
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 8 authors...
ABSTRACT Background Chronic cough is the only symptom of cough variant asthma (CVA) and atopic cough (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness in AC. To evaluate the antitussive effect of montelukast, a leukotriene receptor antagonist, in CVA and AC. Methods Seventy-five patients with chronic cough received diagnostic bronchodilator therapy with oral clenbuterol hydrochloride for 6 days. Of the 75 pati...
27 CitationsSource
■ Abstract Background and objective: Cyclooxygenase (COX) is an enzyme that converts arachidonic acid to prostanoids. There are two isoforms of COX, namely COX-1 and COX-2. COX-2 is highly inducible by several stimuli and is associated with infl ammation. Recent studies have shown that COX-2 is upregulated in the airway epithelium of patients with asthma but little is known about the role it plays in cough, a common symptom of bronchial asthma. This study was designed to investigate the role of ...
16 Citations
#1Toshiyuki KitaH-Index: 15
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 6 authors...
ABSTRACT Background Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling. Objective The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 and 1 dual inhibitor, on chronic airway inflammation and remodeling following chronic exposure to aerosolized antigen in mice. Methods Ovalbumin (OVA) was administered intraperitoneally to BALB/c mice on days 0 and 14, and the mice were then exposed to aerosolized OVA daily for 4 weeks. Twenty-...
15 CitationsSource
#1Johsuke Hara (Kanazawa University)H-Index: 12
#2Masaki FujimuraH-Index: 53
Last. Kazuo KasaharaH-Index: 28
view all 9 authors...
Rationale: We hypothesized that cough stress of the airway wall results in a self-perpetuating cough-reflex cycle in which antigen-induced increase in cough-reflex sensitivity results in pathologic cough, and the cough in turn further amplifies cough-reflex sensitivity.Objectives: To examine cough-reflex sensitivity in an experimental animal model.Methods: We developed an experimental guinea pig model in which airway collapse similar to that in cough was induced by rapid negative pressure applie...
29 CitationsSource
#1Johsuke Hara (Kanazawa University)H-Index: 12
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 23 authors...
ABSTRACT Background 30–80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function of lower airway in adolescents with former asthma. Methods 326 never-smoking young adults (mean age 24.0 years) were interviewed with special emphasis on history of asthma. Diagnosis of asthma was based on GINA guidelines. Former asthma subjects consisted of ones with a history of physician-diagnosed childhood asthma, who had been free of asthma symptoms without ...
13 CitationsSource
#1Miki AboH-Index: 14
#2Kazuyoshi KurashimaH-Index: 21
Last. Tsutomu Kobayashi (Kanazawa University)H-Index: 2
view all 7 authors...
Background and objective: Surfactant dysfunction is a characteristic of bronchial asthma, but mechanisms of dysfunction following antigen exposure are not understood. The aim of this study was to examine whether bronchoalveolar lavage fluid (BALF) has surfactant degradation activity after antigen challenge, using an animal model of asthma. Methods: BALF was collected 24 h after a challenge with aerosolized antigen solution in actively sensitized guinea pigs and from non-sensitized control guinea...
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