Clinical & Experimental Allergy
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4.22
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7969
Papers 8188
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#1Soyoon Sim (Ajou University)H-Index: 2
#2Youngwoo Choi (Ajou University)H-Index: 24
Last. Hae-Sim Park (Ajou University)H-Index: 68
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BACKGROUND Genetic variants of dipeptidyl peptidase 10 (DPP10) have been suggested to contribute to the development of NSAID-exacerbated respiratory disease (NERD). However, the mechanisms of how DPP10 contributes to NERD phenotypes remain unclear. OBJECTIVE To demonstrate the exact role of DPP10 in the pathogenesis of NERD. METHODS Patients with NERD (n = 110), those with aspirin-tolerant asthma (ATA, n = 130) and healthy control subjects (HCs, n = 80) were enrolled. Clinical characteristics we...
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#1Takashi Ishii (Musashino University)H-Index: 2
#2Murakami Yusuke (Musashino University)
Last. Naomi Yamashita (Musashino University)H-Index: 18
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BACKGROUND Myeloid differentiation protein-2 (MD-2) is a lipopolysaccharide-binding protein involved in lipopolysaccharide signalling via Toll-like receptor 4 (TLR4). TLR4 plays an essential role in HDM-mediated allergic airway inflammation. Moreover, MD-2 is structurally similar to Der f 2, a major allergen from house dust mite (HDM). OBJECTIVES We aimed to clarify the role of MD-2 in the pathogenesis of HDM-mediated allergic airway inflammation. METHODS Wild-type (WT), TLR4 knockout and MD-2 k...
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#1M.M.F. van Mierlo (EUR: Erasmus University Rotterdam)
#2Peter J. Caspers (EUR: Erasmus University Rotterdam)H-Index: 28
Last. Suzanne G.M.A. Pasmans (EUR: Erasmus University Rotterdam)H-Index: 28
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#1Qingling Zhang (Guangzhou Medical University)H-Index: 53
#2Wei Luo (Guangzhou Medical University)H-Index: 9
Last. Kefang Lai (Guangzhou Medical University)H-Index: 18
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#1Sergio Souza da Cunha (National Health Service)
Last. Lucy Pembrey (Lond: University of London)H-Index: 14
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BACKGROUND Higher risks of asthma have been observed in children with prenatal exposure to antibiotics and during early life compared to those who have not. However, the causality of such associations is unclear. OBJECTIVE To assess whether exposure to antibiotics in early life had a causal effect in increasing the risk of asthma in children diagnosed at 5-8 years of life, and the impact in the target population. METHODS Data were from electronic health records and questionnaires for children an...
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#1Jessica Bager (KI: Karolinska Institutet)
#2Sandra G. Tedner (Karolinska University Hospital)H-Index: 4
Last. Anna Bergström (KI: Karolinska Institutet)H-Index: 54
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BACKGROUND Tree nut allergy may cause anaphylaxis. There are limited population-based studies on prevalence and early-life risk factors. METHODS We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy. We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16...
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#1Ashley Budu-Aggrey (UoB: University of Bristol)H-Index: 9
Last. Hannah M Sallis (UoB: University of Bristol)H-Index: 20
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BackgroundObservational studies have reported an association between allergic disease and mental health, but a causal relationship has not been established. null ObjectiveTo use Mendelian Randomization (MR) to investigate a possible causal relationship between atopic disease and mental health phenotypes. null MethodsThe observational relationship between allergic disease and mental health was investigated in UK Biobank. The direction of causality was investigated with bidirectional two-sample MR...
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 4
#1Geertje M. de Boer (Erasmus University Medical Center)
Last. Bianca M Boxma-de KlerkH-Index: 1
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BACKGROUND Asthma exacerbations are frequently induced by respiratory tract infections (RTIs). Bacterial lysates have been described to possess immune-modulatory effects and reduce RTIs as well as asthma symptoms in children. However, whether bacterial lysates have similar effects in adult asthma patients is unknown. AIMS To reduce asthma exacerbations by add-on bacterial lysate therapy in adults with severe asthma and to characterize the clinical and immune-modulatory effects of this treatment....
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#1Daniel Munblit (NIH: National Institutes of Health)H-Index: 14
#2Polina Bobkova (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 2
Last. Audrey DunnGalvin (UCC: University College Cork)H-Index: 34
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Background: The long-term sequalae of COVID-19 remain poorly characterised. We assessed persistent symptoms in previously hospitalised patients with COVID-19 and assessed potential risk factors. Methods: Data were collected from patients discharged from 4 hospitals in Moscow, Russia between April 8 and July 10, 2020. Participants were interviewed via telephone using an ISARIC Long-term Follow-up Study questionnaire. Results: 2,649 of 4755 (56%) discharged patients were successfully evaluated, at...
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