Microenvironmental regulation of tumor progression and metastasis
Abstract
Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to...
Paper Details
Title
Microenvironmental regulation of tumor progression and metastasis
Published Date
Nov 1, 2013
Journal
Volume
19
Issue
11
Pages
1423 - 1437
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Notes
History