Nature Medicine
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#1Toni K. Choueiri (Harvard University)H-Index: 116
#2Todd M. Bauer (Sarah Cannon Research Institute)H-Index: 36
Last. Rodolfo F. Perini (MSD: Merck & Co.)H-Index: 21
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Early clinical data for the bispecific antibody teclistamab are encouraging, and further studies are planned. Early clinical data for the bispecific antibody teclistamab are encouraging, and further studies are planned.
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#1Tharick A. PascoalH-Index: 18
#2Andrea Lessa Benedet (McGill University)H-Index: 18
Last. Thomas K. Karikari (University of Gothenburg)H-Index: 16
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Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD). We tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain. We studied 130 individuals across the aging and AD clinical spectrum with positron emission tomography brain imaging for microglial activation ([11C]PBR28), amyloid-β (Aβ) ([18F]AZ...
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#1Na Cai (Wellcome Trust Sanger Institute)H-Index: 14
#2Aurora Gomez-Duran (University of Cambridge)H-Index: 17
Last. Rachael A Lawson (Newcastle University)H-Index: 14
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Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA variants in 16,220 healthy donors, here we show that variants defining mtDNA haplogroups Uk and H4 modulate the level of circulating N-formylmethionine (fMet), which initiates mitochondrial protein translation. In human cytoplasmic hybrid (cybrid) lines, fMet modulated both mitochond...
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#1Netta Mendelson Cohen (Weizmann Institute of Science)H-Index: 8
#2Omer Schwartzman (Tel Aviv Sourasky Medical Center)H-Index: 6
Last. Amos Tanay (Weizmann Institute of Science)H-Index: 57
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Standardized lab tests are central for patient evaluation, differential diagnosis and treatment. Interpretation of these data is nevertheless lacking quantitative and personalized metrics. Here we report on the modeling of 2.1 billion lab measurements of 92 different lab tests from 2.8 million adults over a span of 18 years. Following unsupervised filtering of 131 chronic conditions and 5,223 drug–test pairs we performed a virtual survey of lab tests distributions in healthy individuals. Age and...
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#1Andrey N. Petrov (UNI: University of Northern Iowa)H-Index: 14
#2Mark R. Welford (UNI: University of Northern Iowa)H-Index: 6
Last. Alexander Savelyev (Texas State University)H-Index: 6
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A study shows how fermented foods such as keffir and kimchi enhance microbiome diversity and reduce markers of inflammation. A study shows how fermented foods such as keffir and kimchi enhance microbiome diversity and reduce markers of inflammation.
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#1Emily Breza (Harvard University)H-Index: 9
#2Fatima Cody Stanford (Harvard University)H-Index: 17
Last. Kelly Holland (Lynn University)
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During the Coronavirus Disease 2019 (COVID-19) epidemic, many health professionals used social media to promote preventative health behaviors. We conducted a randomized controlled trial of the effect of a Facebook advertising campaign consisting of short videos recorded by doctors and nurses to encourage users to stay at home for the Thanksgiving and Christmas holidays ( NCT04644328 and AEARCTR-0006821 ). We randomly assigned counties to high intensity (n = 410 (386) at Thanksgiving (Christmas))...
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#1Joel S. Perlmutter (WashU: Washington University in St. Louis)H-Index: 78
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#1Jeffrey L. Cummings (UNLV: University of Nevada, Las Vegas)H-Index: 166
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