Response Inhibition Predicts Poor Antidepressant Treatment Response in Very Old Depressed Patients

Objective There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression. Methods Growth curve models were fit to data from the only 8-week, double-blind, placebo controlled trial of citalopram (20–40 mg/day) in patients aged 75 years and older with unipolar depression. Baseline assessment included Structured Clinical Interview...