Original paper
Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets
Abstract
Protease activated receptor-4 (PAR4) is one of the thrombin receptors on human platelets and is a potential target for the management of thrombotic disorders. We sought to develop potent, selective, and novel PAR4 antagonists to test the role of PAR4 in thrombosis and hemostasis. Development of an expedient three-step synthetic route to access a novel series of indole-based PAR4 antagonists also necessitated the development of a platelet based...
Paper Details
Title
Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets
Published Date
Jun 11, 2013
Journal
Volume
8
Issue
6
Pages
e65528 - e65528
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Notes
History