Original paper
Substrate stress relaxation regulates cell spreading
Abstract
Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM. However, these studies typically utilize purely elastic materials as substrates, whereas physiological ECMs are viscoelastic, and exhibit stress relaxation, so that cellular traction forces exerted by cells remodel the ECM. Here we investigate the influence...
Paper Details
Title
Substrate stress relaxation regulates cell spreading
Published Date
Feb 19, 2015
Journal
Volume
6
Issue
1
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Notes
History