David J. Mooney
Wyss Institute for Biologically Inspired Engineering
Self-healing hydrogelsBiophysicsBiomedical engineeringCellRegeneration (biology)NanotechnologyChemistryExtracellular matrixMaterials scienceMesenchymal stem cellImmunologyIn vivoVascular endothelial growth factorAngiogenesisTransplantationTissue engineeringPolymerMedicineBiologyCell biology
771Publications
164H-index
89.2kCitations
Publications 626
Newest
#1Benjamin R. Freedman (Wyss Institute for Biologically Inspired Engineering)H-Index: 20
#2Oktay Uzun (Wyss Institute for Biologically Inspired Engineering)H-Index: 19
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 164
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The development of tough adhesive hydrogels has enabled unprecedented adhesion to wet and moving tissue surfaces throughout the body, but they are typically composed of nondegradable components. Here, a family of degradable tough adhesive hydrogels containing ≈90% water by incorporating covalently networked degradable crosslinkers and hydrolyzable ionically crosslinked main-chain polymers is developed. Mechanical toughness, adhesion, and degradation of these new formulations are tested in both a...
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#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)
#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)H-Index: 9
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 164
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Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.
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#1Yiwei Li (MIT: Massachusetts Institute of Technology)H-Index: 13
#2Angelo S. Mao (Harvard University)H-Index: 16
Last. Ming Guo (MIT: Massachusetts Institute of Technology)H-Index: 17
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Current methods to obtain mesenchymal stem cells (MSCs) involve sampling, culturing, and expanding of primary MSCs from adipose, bone marrow, and umbilical cord tissues. However, the drawbacks are the limited numbers of total cells in MSC pools, and their decaying stemness during in vitro expansion. As an alternative resource, recent ceiling culture methods allow the generation of dedifferentiated fat cells (DFATs) from mature adipocytes. Nevertheless, this process of spontaneous dedifferentiati...
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#1Alexander J. Najibi (Harvard University)H-Index: 5
#2Nisarg J. Shah (Harvard University)H-Index: 16
Last. David J. Mooney (Harvard University)H-Index: 164
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Acute myeloid leukemia (AML) is a hematopoietic malignancy with limited therapeutic options. Standard-of-care chemotherapy depletes AML cells to induce remission, but often precedes disease relapse. To promote robust and durable immunity against AML, we developed a macroporous cryogel-based vaccine which provided a sustained release of GM-CSF to concentrate dendritic cells (DCs), TLR agonist CpG-ODN, and leukemia antigen. Prophylactic vaccination in mice against AML cell lysates or peptide antig...
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#1Sungmin Nam (Wyss Institute for Biologically Inspired Engineering)H-Index: 12
#1Sungmin Nam (Harvard University)
Last. David J. Mooney (Harvard University)H-Index: 164
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Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their nu...
3 CitationsSource
#1Avi Smith (Tufts University)H-Index: 10
#2Trishawna Watkins (Tufts University)H-Index: 1
Last. Jonathan A. Garlick (Tufts University)H-Index: 33
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A major challenge in the management of patients suffering from diabetes is the risk of developing nonhealing foot ulcers. Most in vitro methods to screen drugs for wound healing therapies rely on conventional 2D cell cultures that do not closely mimic the complexity of the diabetic wound environment. In addition, while three-dimensional (3D) skin tissue models of human skin exist, they have not previously been adapted to incorporate patient-derived macrophages to model inflammation from these wo...
1 CitationsSource
#1Berna Özkale (Wyss Institute for Biologically Inspired Engineering)H-Index: 1
#1Berna Özkale (Wyss Institute for Biologically Inspired Engineering)H-Index: 10
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 164
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Active biomaterials offer novel approaches to study mechanotransduction in mammalian cells. These material systems probe cellular responses by dynamically modulating their resistance to endogenous forces or applying exogenous forces on cells in a temporally controlled manner. Stimuli-responsive molecules, polymers, and nanoparticles embedded inside cytocompatible biopolymer networks transduce external signals such as light, heat, chemicals, and magnetic fields into changes in matrix elasticity (...
4 CitationsSource
#1Stefanie P. Lazow (Boston Children's Hospital)H-Index: 4
#2Daniel F. Labuz (Boston Children's Hospital)H-Index: 2
Last. Dario O. Fauza (Boston Children's Hospital)H-Index: 44
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Abstract Background/purpose We sought to test select properties of a novel, expandable bioadhesive composite that allows for enhanced adhesion control in liquid environments. Methods Rabbit fetuses (n = 23) underwent surgical creation of spina bifida on gestational day 22–25 (term 32–33 days). Defects were immediately covered with a two-component tough adhesive consisting of a hydrogel made of a double network of ionically crosslinked alginate and covalently crosslinked polyacrylamide linked to ...
1 CitationsSource
#1R. Warren Sands (Harvard University)H-Index: 4
#2Inna Tabansky (SBU: Stony Brook University)
Last. David J. Mooney (Harvard University)H-Index: 164
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Diseases of immunity, including autoimmune diseases such as multiple sclerosis, transplantation graft rejection, allergy, and asthma, are prevalent and increasing in prevalence. They contribute to significant morbidity and mortality; however, few if any curative therapies exist, and those that are available lack either potency or specificity. Dendritic cells (DCs) are sentinels of the immune system that connect the innate and adaptive immune system and are critical regulators of both immunity an...
1 CitationsSource
#1Ainhoa Gonzalez-Pujana (UPV/EHU: University of the Basque Country)H-Index: 6
#2Irene de Lázaro (Wyss Institute for Biologically Inspired Engineering)H-Index: 10
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 164
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Human mesenchymal stromal cells (hMSCs) hold great promise in the treatment of inflammatory and immune diseases, due to their immunomodulatory capacity. Their therapeutic activity is often assessed measuring levels of expression of immunomodulatory genes such as indoleamine 2,3-dioxygenase 1 (IDO1) and real-time RT-qPCR is most predominantly the method of choice due to its high sensitivity and relative simplicity. Currently, multiple strategies are explored to promote hMSC-mediated immunomodulat...
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