Synthesis and Preclinical Characterization of [18F]FPBZA: A Novel PET Probe for Melanoma
Abstract
Benzamide can specifically bind to melanoma cells. A 18F-labeled benzamide derivative, [18F]N-(2-diethylaminoethyl)-4-[2-(2-(2-fluoroethoxy) ethoxy)ethoxy]benzamide ([18F]FPBZA), was developed as a promising PET probe for primary and metastatic melanoma.[18F]FPBZA was synthesized via a one-step radiofluorination in this study. The specific uptake of [18F]FPBZA was studied in B16F0 melanoma cells, A375 amelanotic melanoma cells, and...
Paper Details
Title
Synthesis and Preclinical Characterization of [18F]FPBZA: A Novel PET Probe for Melanoma
Published Date
Jan 1, 2014
Volume
2014
Pages
1 - 11
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