Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue
Abstract
Protein S has an important anticoagulant function by acting as a cofactor for activated protein C (APC). We recently reported that the EGF1 domain residue Asp95 is critical for APC cofactor function. In the present study, we examined whether additional interaction sites within the Gla domain of protein S might contribute to its APC cofactor function. We examined 4 residues, composing the previously reported “Face1” (N33S/P35T/E36A/Y39V) variant,...
Paper Details
Title
Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue
Published Date
Jun 16, 2011
Journal
Volume
117
Issue
24
Pages
6685 - 6693
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