Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
Abstract
Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote tumorigenesis remain incompletely characterized. Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative...
Paper Details
Title
Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
Published Date
Oct 3, 2014
Journal
Volume
346
Issue
6205
Pages
85 - 89
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