Low-Activity 124I-PET/Low-Dose CT Versus 131I Probe Measurements in Pretherapy Assessment of Radioiodine Uptake in Benign Thyroid Diseases

Published on Feb 25, 2014in The Journal of Clinical Endocrinology and Metabolism5.958
· DOI :10.1210/JC.2013-4390
Julian G. Westphal2
Estimated H-index: 2
Thomas Winkens10
Estimated H-index: 10
+ 1 AuthorsMartin Freesmeyer15
Estimated H-index: 15
Context: Radioiodine therapy of benign thyroid diseases requires pretherapy assessment of radioactive iodine uptake (RAIU) for reliable therapy planning. Objective: Our objective was to assess RAIU by low-activity 124I-positron emission tomography/low-dose computed tomography (124I-PET/CT) in comparison with standard 131I probe measurements. Design/Setting: This prospective comparative study was conducted at the Jena University Hospital, Jena, Germany, in a referral center setting. Patients: A total of 79 patients with benign thyroid diseases were screened, 40 of whom met the inclusion criteria (stable TSH, free T3 and free T4 levels; no thyroid-specific medication, no iodine contamination) and 24 of whom agreed to participate by signing an informed consent. Interventions: All patients received the standard 131I scintillation probe uptake test 30 hours after administration of 3 MBq 131I. Seven days later, all patients were subjected to 124I-PET/CT uptake measurement 30 hours after administration of 1 MBq ...
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