Thomas Winkens
University of Jena
Imaging phantomRadiologyPET-CTBiomedical engineeringPathologyUltrasoundRetrospective cohort studyPositron emission tomographyBiopsyThyroid nodulesScintigraphyNuclear medicineThyroid carcinomaIn patientVolume (compression)ThyroidUltrasonographyComputed tomographyImage fusionMedicine
57Publications
9H-index
302Citations
Publications 58
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#1Philipp Seifert (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 9
#2Julia GreiserH-Index: 3
Last. Martin FreesmeyerH-Index: 14
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ABSTRACT: A 68-year-old woman was referred with the diagnosis of symptomatic pHPT (primary hyperparathyroidism). Ultrasonography (US) and 99mTc-MIBI scintigraphy could not clearly identify a parathyroid adenoma. A primary unilateral surgical exploration remained unsuccessful to remove adenomatous parathyroid tissue and the pHPT persisted. 18F-ethylcholine PET/CT showed a left-sided retropharyngeal lesion with intense tracer uptake that could not be detected on US images at first sight. Therefore...
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#1Thomas WinkensH-Index: 9
Last. Martin FreesmeyerH-Index: 14
view all 7 authors...
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PURPOSE FDG PET/CT has been described for noninvasive grading, detection of extrahepatic spread, and recurrence in hepatocellular carcinoma (HCC). As compared with localized imaging approaches (MRI, ultrasonography), FDG PET/CT not only focuses on the liver, but covers a long field of view from the base of the skull to the thighs, visualizing pathologic findings not related to HCC. The aims of this retrospective study were to (1) describe the frequency of relevant incidental findings on FDG PET/...
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#1Martin FreesmeyerH-Index: 2
#2Julia GreiserH-Index: 3
Last. Robert DrescherH-Index: 5
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Established imaging modalities for the characterization of liver tumors are computed tomography (CT), magnetical resonance (MR) imaging, sonography, and hepatobiliary scintigraphy. In some cases, their results may be inconclusive or certain examinations not possible due to contraindications. Positron emission tomography (PET)/CT has the capability of dynamic imaging with high temporal resolution. With radiolabeled tri-alkoxysalicyl-1,4-diazepan-6-amine (TAoS-DAZA) tracers, imaging of liver perfu...
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#1Philipp SeifertH-Index: 9
Last. Martin FreesmeyerH-Index: 2
view all 7 authors...
Conventional ultrasound (US) is time-consuming, and results are subjected to high interobserver variability. In this study, the reliability of a novel thyroid US cine loop standard operating procedure (SOP) applied by non-physicians (Medical Technical Assistant, MTA) is investigated. Thirty-three consecutive patients (22 females, 11 males) were enrolled. Patients underwent conventional thyroid US performed by a nuclear medicine physician and additional MTA US cine loop according to a local SOP t...
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#1Martin FreesmeyerH-Index: 14
#2Thomas WinkensH-Index: 9
Last. Philipp SeifertH-Index: 9
view all 8 authors...
In conventional thyroid diagnostics, the topographical correlation between thyroid nodules (TN) depicted on ultrasound (US) in axial or sagittal orientation and coronally displayed scintigraphy images can be challenging. Sensor-navigated I-124-PET/US fusion imaging has been introduced as a problem-solving tool for ambiguous cases. The purpose of this study was to investigate the results of multiple unexperienced medical students (MS) versus multiple nuclear medicine physicians (MD) regarding the...
2 CitationsSource
52 Background: Conventional diagnostics (CD) of thyroid nodules (TN) comprises ultrasound (US) and scintigraphy scans. Combining these two modalities can lead to uncertain or incorrect topographic assignments. Hybrid imaging is an established and successful solution for many issues in nuclear medicine. However, research data on SPECT/US and PET/US fusion imaging of the thyroid are scarce. The present data firstly represent the value of fusion imaging in the field of TN diagnostics on the basis o...
1122 Objectives: Preclinical nuclear medicine research usually is based on classic animal models using rats and mice. Prerequisites comprise adequate premises, small-animal scanners and personnel. In-ovo imaging has been described for small chicken eggs and as experiments are performed before hatching, this does not qualify as animal research. However, this approach still requires small-animal scanners. We report on the use of large ostrich eggs (Struthio camelus) on PET/CT used for routine clin...
AIM: Intravenous radionuclide therapies are gaining importance. With the increased frequency of these therapies, safe application procedures in combination with effective radiation protection are needed. We present a shielded system which can be universally used for the application of liquid radiopharmaceuticals. MATERIALS AND METHODS: The application system consists of a cuboidal box made of lead with stainless steel coating, an inner layer of polymethyl methacrylate (PMMA), a disposable line/b...
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Aim To proof the feasibility of manufacturing patient-indivdual (anthropomorphic) thyroid replicas from I-124 PET DICOM datasets by means of 3D printing. A possible field of application is the use of those phantoms for the calibration of gamma probes. Methods After editing of the DICOM datasets using several software types and transferring into a dedicated stereolithography format, 10 fillable thyroid replicas (35–200 mL) made of polylactide acid were manufactured via 3D printing. All replicas w...
3 CitationsSource