Epimedium-Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24-Month Randomized, Double-Blind and Placebo-Controlled Trial

Epimedium brevicornum maxim , a nonleguminous medicinal plant, has been found to be rich in phytoestrogen flavonoids. Results from a 24‐month randomized double‐blind placebo‐controlled clinical trial showed that Epimedium ‐derived phytoestrogen flavonoids were able to exert beneficial effects on preventing bone loss in late postmenopausal women, without resulting in a detectable hyperplasia effect on the endometrium. Introduction : We performed...