Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends.

Published on Jun 1, 2015in Biomaterials10.317
· DOI :10.1016/J.BIOMATERIALS.2015.02.110
Taimoor H. Qazi11
Estimated H-index: 11
David J. Mooney165
Estimated H-index: 165
(Harvard University)
+ 2 AuthorsGeorg N. Duda88
Estimated H-index: 88
Abstract Skeletal muscles have a robust capacity to regenerate, but under compromised conditions, such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in the field of skeletal muscle tissue engineering has elucidated multiple intrinsic mechanisms of skeletal muscle repair, and has thus sought to identify various types of cells and bioactive factors which play an important role during regeneration. In order to maximize the potential therapeutic effects of cells and growth factors, several biomaterial based strategies have been developed and successfully implemented in animal muscle injury models. A suitable biomaterial can be utilized as a template to guide tissue reorganization, as a matrix that provides optimum micro-environmental conditions to cells, as a delivery vehicle to carry bioactive factors which can be released in a controlled manner, and as local niches to orchestrate in situ tissue regeneration. A myriad of biomaterials, varying in geometrical structure, physical form, chemical properties, and biofunctionality have been investigated for skeletal muscle tissue engineering applications. In the current review, we present a detailed summary of studies where the use of biomaterials favorably influenced muscle repair. Biomaterials in the form of porous three-dimensional scaffolds, hydrogels, fibrous meshes, and patterned substrates with defined topographies, have each displayed unique benefits, and are discussed herein. Additionally, several biomaterial based approaches aimed specifically at stimulating vascularization, innervation, and inducing contractility in regenerating muscle tissues are also discussed. Finally, we outline promising future trends in the field of muscle regeneration involving a deeper understanding of the endogenous healing cascades and utilization of this knowledge for the development of multifunctional, hybrid, biomaterials which support and enable muscle regeneration under compromised conditions.
📖 Papers frequently viewed together
11.5k Citations
342 Citations
10 Authors (Penney M. Gilbert, ..., Helen M. Blau)
1,267 Citations
#1Apoorva S. Salimath (Parker H. Petit Institute for Bioengineering & Bioscience)H-Index: 1
#2Andrés J. García (Parker H. Petit Institute for Bioengineering & Bioscience)H-Index: 90
Hydrogel scaffolds encapsulating C2C12 mouse skeletal muscle cells have been engineered as in vitro constructs towards regenerative medicine therapies for the enhancement and inducement of functional skeletal muscle formation. Previous work has largely involved two-dimensional (2D) muscle strips, naturally occurring hydrogels and incomplete examination of the effects of the scaffold and/or biological functionalization on myogenic differentiation in a controllable manner. The goal of this study w...
30 CitationsSource
#1Rishma Shah (UCL Eastman Dental Institute)H-Index: 10
#2Jonathan C. Knowles (UCL Eastman Dental Institute)H-Index: 91
Last. Mark P. Lewis (UCL Eastman Dental Institute)H-Index: 41
view all 4 authors...
Skeletal muscle defects are notoriously difficult to manage and the current methods used are associated with many limitations. Engineered skeletal muscle tissue has the potential to provide a solution that circumvents these disadvantages. Our previous work has identified a novel three-dimensionally aligned degradable phosphate glass fibre scaffold that can support myoblast differentiation and maturation. This current study has further developed the scaffold by encasing the fibres within a collag...
23 CitationsSource
#1Dariusz RakusH-Index: 25
#2Agnieszka GizakH-Index: 22
Last. Jacek R. Wiśniewski (MPG: Max Planck Society)H-Index: 38
view all 4 authors...
Slow and fast skeletal muscles are composed of, respectively, mainly oxidative and glycolytic muscle fibers, which are the basic cellular motor units of the motility apparatus. They largely differ in excitability, contraction mechanism, and metabolism. Because of their pivotal role in body motion and homeostasis, the skeletal muscles have been extensively studied using biochemical and molecular biology approaches. Here we describe a simple analytical and computational approach to estimate titers...
28 CitationsSource
#1Serge Ostrovidov (Tohoku University)H-Index: 25
#2Vahid Hosseini (ETH Zurich)H-Index: 13
Last. Ali KhademhosseiniH-Index: 147
view all 9 authors...
Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two decades after the introduction of SMTE, the engineering of functional skeletal muscle in the laboratory still remains a great challenge, and numerous techniques for growing functional muscle tissues are constantly being developed. This article reviews the recent findings regarding the methodology and various technical ...
115 CitationsSource
#1Lin WangH-Index: 5
#2Lan Cao (Harvard University)H-Index: 10
Last. Herman H. Vandenburgh (Brown University)H-Index: 43
view all 6 authors...
Repair of injured skeletal muscle by cell therapies has been limited by poor survival of injected cells. Use of a carrier scaffold delivering cells locally, may enhance in vivo cell survival, and promote skeletal muscle regeneration. Biomaterial scaffolds are often implanted into muscle tissue through invasive surgeries, which can result in trauma that delays healing. Minimally invasive approaches to scaffold implantation are thought to minimize these adverse effects. This hypothesis was address...
55 CitationsSource
#1Dmitry Shvartsman (Wyss Institute for Biologically Inspired Engineering)H-Index: 16
#2Hannah Storrie-White (Harvard University)H-Index: 1
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 165
view all 14 authors...
Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced b...
57 CitationsSource
#1Swathi Rangarajan (Duke University)H-Index: 1
#2Lauran Madden (Duke University)H-Index: 6
Last. Nenad Bursac (Duke University)H-Index: 52
view all 3 authors...
The field of tissue engineering involves design of high-fidelity tissue substitutes for predictive experimental assays in vitro and cell-based regenerative therapies in vivo. Design of striated muscle tissues, such as cardiac and skeletal muscle, has been particularly challenging due to a high metabolic demand and complex cellular organization and electromechanical function of the native tissues. Successful engineering of highly functional striated muscles may thus require creation of biomimetic...
59 CitationsSource
#1Richard Balint (University of Manchester)H-Index: 8
#2Nigel J. Cassidy (Keele University)H-Index: 24
Last. Sarah H. Cartmell (University of Manchester)H-Index: 28
view all 3 authors...
Abstract Developing stimulus-responsive biomaterials with easy-to-tailor properties is a highly desired goal of the tissue engineering community. A novel type of electroactive biomaterial, the conductive polymer, promises to become one such material. Conductive polymers are already used in fuel cells, computer displays and microsurgical tools, and are now finding applications in the field of biomaterials. These versatile polymers can be synthesised alone, as hydrogels, combined into composites o...
797 CitationsSource
#1Taimoor H. Qazi (FAU: University of Erlangen-Nuremberg)H-Index: 11
#2Ranjana Rai (FAU: University of Erlangen-Nuremberg)H-Index: 15
Last. Aldo R. Boccaccini (FAU: University of Erlangen-Nuremberg)H-Index: 114
view all 8 authors...
Cardiovascular diseases, especially myocardial infarction, are the leading cause of morbidity and mortality in the world, also resulting in huge economic burdens on national economies. A cardiac patch strategy aims at regenerating an infarcted heart by providing healthy functional cells to the injured region via a carrier substrate, and providing mechanical support, thereby preventing deleterious ventricular remodeling. In the present work, polyaniline (PANI) was doped with camphorsulfonic acid ...
120 CitationsSource
#1Brian M. Sicari (University of Pittsburgh)H-Index: 20
#2J. Peter Rubin (University of Pittsburgh)H-Index: 60
Last. Stephen F. Badylak (University of Pittsburgh)H-Index: 136
view all 15 authors...
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with periva...
263 CitationsSource
Cited By195
#1Michael T.K. Bramson (RPI: Rensselaer Polytechnic Institute)H-Index: 2
#2Sarah K. Van Houten (RPI: Rensselaer Polytechnic Institute)H-Index: 1
Last. David T. Corr (RPI: Rensselaer Polytechnic Institute)H-Index: 22
view all 3 authors...
Tendon, ligament, and skeletal muscle are highly-organized tissues that largely rely on a hierarchical collagenous matrix to withstand high tensile loads experienced in activities of daily life. This critical biomechanical role predisposes these tissues to injury, and current treatments fail to recapitulate the biomechanical function of native tissue. This has prompted researchers to pursue engineering functional tissue replacements, or dysfunction/disease/development models, by emulating in viv...
#1Ji Min Seok (SNU: Seoul National University)H-Index: 6
#2Goeun Choe (Gwangju Institute of Science and Technology)H-Index: 6
Last. Su A ParkH-Index: 29
view all 0 authors...
Abstract null null For further advance a functionality of three-dimensional (3D) printing techniques using biopolymers, graphene oxide (GO) as a carbon-based nanomaterial has received much attention recently due to its superior properties. However, the ability to synergistically affect the resulting 3D-printed structures has been limited by difficulty controlling the nanomaterial ratio in which biological stability is achieved, as well as by the use of noxious solvents applied to the nanomateria...
#1Tianli Hu (Xi'an Jiaotong University)H-Index: 7
#2Mengting Shi (Xi'an Jiaotong University)H-Index: 6
Last. Baolin Guo (Xi'an Jiaotong University)H-Index: 57
view all 0 authors...
Abstract null null Developing 3D conductive aligned cryogels has great potential for skeletal muscle trauma treatment because they can mimic anisotropic structure, conductivity, and recoverable cyclic compression of the microenvironment of native skeletal muscle. In this work, a series of cryogels possessing 3D aligned morphology, conductivity, and excellent anisotropic mechanical compression property based on gelatin (GT) and polydopamine coated carbon nanotubes (PCNTs) were fabricated as skele...
#1Indong Jun (KIST: Korea Institute of Science and Technology)H-Index: 17
#2Hyung-Seop Han (KIST: Korea Institute of Science and Technology)H-Index: 14
Last. Heungsoo Shin (Hanyang University)H-Index: 49
view all 0 authors...
The utilization of cell-manipulating techniques reveals information about biological behaviors suited to address a wide range of questions in the field of life sciences. Here, we introduced an on/off switchable physical stimuli technique that offers precise stimuli for reversible cell patterning to allow regulation of the future direction of adherent cellular behavior by leveraging enzymatically degradable alginate hydrogels with defined chemistry and topography. As a proof of concept, targeted ...
#1Jasmine Si Han Seah (NTU: Nanyang Technological University)H-Index: 1
#2Satnam Singh (Agency for Science, Technology and Research)H-Index: 6
Last. Deepak Choudhury (Agency for Science, Technology and Research)H-Index: 14
view all 0 authors...
The cultured meat market has been growing at an accelerated space since the first creation of cultured meat burger back in 2013. Substantial efforts have been made to reduce costs by eliminating serum in growth media and improving process efficiency by employing bioreactors. In parallel, efforts are also being made on scaffolding innovations to offer better cells proliferation, differentiation and tissue development. So far, scaffolds used in cultured meat research are predominantly collagen and...
#6Xiaomeng Li (Zhengzhou University)H-Index: 9
#7Qian Li (Zhengzhou University)H-Index: 24
Electrospun nanofibers have been frequently used for tissue engineering due to their morphological similarities with the extracellular matrix (ECM) and tunable chemical and physical properties for regulating cell behaviors and functions. However, most of the existing electrospun nanofibers have a closely packed two-dimensional (2D) membrane with the intrinsic shortcomings of limited cellular infiltration, restricted nutrition diffusion, and unsatisfied thickness. Three-dimensional (3D) electrosp...
The development of robust skeletal muscle models has been challenging due to the partial recapitulation of human physiology and architecture. Reliable and innovative 3D skeletal muscle models recently described offer an alternative that more accurately captures the in vivo environment but require an abundant cell source. Direct reprogramming or transdifferentiation has been considered as an alternative. Recent reports have provided evidence for significant improvements in the efficiency of deriv...
#1Emine Alarçin (Marmara University)H-Index: 8
#2Ayça Bal-OzturkH-Index: 2
Last. Meltem Avci-AdaliH-Index: 17
view all 9 authors...
Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high dem...
#1Miranda M. Carleton (U of T: University of Toronto)H-Index: 2
#2Michael V. Sefton (U of T: University of Toronto)H-Index: 56
Skeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle integrity and function following severe injury. Consequently, numerous tissue engineering techniques, both acellular and with cells, are being investigated to enhance muscle regeneration. Biomaterials are an essential part of these techniques as they...
#1Hyeongjin Lee (Wake Forest Institute for Regenerative Medicine)H-Index: 5
#2WonJin Kim (SKKU: Sungkyunkwan University)H-Index: 12
Last. Sang Jin Lee (Wake Forest Institute for Regenerative Medicine)H-Index: 55
view all 8 authors...
To achieve rapid skeletal muscle function restoration, many attempts have been made to bioengineer functional muscle constructs by employing physical, biochemical, or biological cues. Here, we develop a self-aligned skeletal muscle construct by printing a photo-crosslinkable skeletal muscle extracellular matrix-derived bioink together with poly(vinyl alcohol) that contains human muscle progenitor cells. To induce the self-alignment of human muscle progenitor cells, in situ uniaxially aligned mic...