Last. Huangxian Ju(NU: Nanjing University)H-Index: 113
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Abstract null null Chemodynamic therapy (CDT) is an ideal therapeutic modality with endogenous H2O2 as stimulus. Most intracellular H2O2 supplement strategies for improving CDT efficiency are strongly rely on oxygen participation, and the hypoxia tumor microenvironment impairs their performance. Here we develop a self-assembled metal-organic coordinated nanoparticle Cu-OCNP/Lap with NIR-II reinforced intracellular cyclic reaction to enhance CDT efficiency. Cu-OCNP/Lap is synthesized using Cu2+ a...
Abstract null null null Proper manipulation of tumorigenic null microenvironment null s has been considered as one of the most effective approaches for tumor therapy, which is still a challenge to be well performed. Herein, a nano-modulator was fabricated to manipulate the hypoxia, glucose, radicals and local temperature in tumor tissue as needed, which consists of hemoglobin (Hb) and ferric ion (Fe3+ null ) co-conjugated polydopamine (PDA) as core, null glucose oxidase null (GOD) as shell, and ...
Abstract null null null null Unlike full-thickness cartilage defects (FCD), partial-thickness cartilage defects (PCD) may still have residual healthy cartilage tissue, and therefore, the conventional clinical treatments such as null microfracture null null and autologous null chondrocyte null implantation (ACI) are so traumatic that they may not be the suitable therapies for PCD. Although intra-articular injection of null null null mesenchymal stem cells null null null null (MSCs) is a minimally...
Last. Maria Asplund(Luleå University of Technology)H-Index: 15
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Abstract null null null null Electrotaxis is a naturally occurring phenomenon in which ionic gradients dictate the directed migration of cells involved in different null biological processes null such as wound healing, null null embryonic development , or cancer metastasis. To investigate these processes, direct current (DC) has been used to generate electric fields capable of eliciting an electrotactic response in cells. However, the need for metallic electrodes to deliver said currents has hin...
#1Tianyi Kang(Southern University of Science and Technology)H-Index: 3
#2Jen-Shyang Ni(Southern University of Science and Technology)H-Index: 18
Last. Kai Li(Southern University of Science and Technology)H-Index: 73
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Abstract One major challenge in miRNA-based therapy is to explore facile delivery strategies, which can facilitate the efficient and precise accumulation of intrinsically instable microRNAs (miRNAs) at targeted tumor sites. To address this critical issue, for the first time we demonstrate that a near-infrared (NIR) pulse laser can guide efficient delivery of miRNAs mediated by a NIR-absorbing and photoacoustic active semiconducting polymer (SP) nanocarrier, which can generate photoacoustic radia...
#1Shuhong Kuang(SYSU: Sun Yat-sen University)H-Index: 1
#2Feng He(SCUT: South China University of Technology)
Last. Chunhua Deng(SYSU: Sun Yat-sen University)H-Index: 16
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Abstract null null Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-based therapies for tissue repair have been limited. Genetic engineering could endow MSCs with more robust regenerative capacities. Here, we identified that C-C motif chemokine receptor 2 (CCR2) overexpression enhanced the targeted migration and immunoregulatory potential of MSCs in response to C-C motif chemokine ligand 2 (CCL2) i...
Abstract null null Breast cancer treatment needs to eradicate cancer cells and restore breast defects after surgical intervention. Herein, bifunctional composite scaffolds of black phosphorus nanosheets (BPNSs) and gelatin were designed to kill breast cancer cells and induce adipose tissue reconstruction. The composite scaffolds were prepared by hybridizing photothermal BPNSs with porous gelatin matrices by adding pre-prepared ice particles to precisely adjust their pore structures. The composit...
Last. Barbara P. Chan(HKU: University of Hong Kong)H-Index: 31
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Abstract Cells can sense mechanical signals through cytoskeleton reorganization. We previously discovered the formation of omni-directional actin protrusions upon compression loading, namely compression-induced actin protrusions (CAPs), in human mesenchymal stem cells (MSCs) in 3D micro-tissues. Here, the regulatory roles of three RhoGTPases (CDC42, Rac1 and RhoA) in the formation of CAPs were investigated. Upon compression loading, extensive formation of CAPs was found, significantly associated...
#1Wenbo Wu(NUS: National University of Singapore)H-Index: 36
#2Leilei Shi(NUS: National University of Singapore)H-Index: 15
Last. Bin Liu(NUS: National University of Singapore)H-Index: 148
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Photodynamic therapy (PDT) is a promising noninvasive treatment option for patients suffering from superficial tumors, such as oral cancer. However, for photosensitizers (PSs), it remains a grand challenge to simultaneously excel in all the key performance indicators including effective singlet oxygen (1O2) generation under clinical laser, specific targeting function and stable far-red (FR)/near-infrared (NIR) emission with low dark toxicity. In addition, traditional PS nanoparticles (NPs) for c...
Abstract Recently, use of cell sheets with bio-applicable fabrication materials for transplantation has been an attractive approach for the treatment of patients with liver failure. However, renewable and scalable cell sources for engineered tissue patches remain limited. We previously reported a new type of proliferating bipotent human chemically derived hepatic progenitor cells (hCdHs) developed by small molecule-mediated reprogramming. Here, we developed a patient-specific hepatic cell sheet ...