Comparison between hypertonic and isotonic saline‐induced sputum in the evaluation of airway inflammation in subjects with moderate asthma

Hypertonic saline-induced sputum has recently been used for the evaluation of airway inflammation in asthma.To assess the effect of hypertonicity on airway inflammation.We compared the inflammatory cell composition of hypertonic saline-induced sputum with that of isotonic saline-induced sputum in 21 asthmatic subjects and, at baseline and 30 min after each sputum induction, we measured bronchial hyper-responsiveness to methacholine as an...