Original paper

The Skeletal Structure of Insulin‐Like Growth Factor I‐Deficient Mice

Volume: 16, Issue: 12, Pages: 2320 - 2329
Published: Dec 1, 2001
Abstract
The importance of insulin-like growth factor I (IGF-I) for growth is well established. However, the lack of IGF-I on the skeleton has not been examined thoroughly. Therefore, we analyzed the structural properties of bone from mice rendered IGF-I deficient by homologous recombination (knockout [k/o]) using histomorphometry, peripheral quantitative computerized tomography (pQCT), and microcomputerized tomography (muCT). The k/o mice were 24% the...
Paper Details
Title
The Skeletal Structure of Insulin‐Like Growth Factor I‐Deficient Mice
Published Date
Dec 1, 2001
Volume
16
Issue
12
Pages
2320 - 2329
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