FDG PET/CT in oncology: "raising the bar".

Published on Jul 1, 2010in Clinical Radiology2.118
· DOI :10.1016/J.CRAD.2010.01.003
Chirag Patel11
Estimated H-index: 11
(Churchill Hospital),
C.N. Patel1
Estimated H-index: 1
(Churchill Hospital)
+ 1 AuthorsAndrew Scarsbrook26
Estimated H-index: 26
(Leeds Teaching Hospitals NHS Trust)
Sources
Abstract
Integrated positron-emission tomography/computed tomography (PET/CT) with 2-[ 18 F]-fluoro-2-deoxy- d- glucose (FDG) has revolutionized oncological imaging in recent years and now has a firmly established role in a variety of tumour types. There have been simultaneous step-wise advances in scanner technology, which are yet to be exploited to their full potential in clinical practice. This article will review these technological developments and explore how refinements in imaging protocols can further improve the accuracy and efficacy of PET/CT in oncology. The promises, and limitations, of emerging oncological applications of FDG PET/CT in radiotherapy planning and therapy response assessment will be explored. Potential future developments, including the use of FDG PET probes in oncological surgery, advanced data analysis techniques, and the prospect of integrated PET/magnetic resonance imaging (PET/MRI) will be highlighted.
📖 Papers frequently viewed together
25 Citations
2,039 Citations
186 Citations
References114
Newest
#2Valerie TreyerH-Index: 36
Last. Thomas F. HanyH-Index: 49
view all 8 authors...
Objective To integrate CT-perfusion into a routine, clinical contrast-enhanced (ce) PET/CT protocol for the evaluation of liver metastases and to compare functional CT and PET parameters.
26 CitationsSource
#1Heinz Peter Schlemmer (Siemens)H-Index: 1
Last. Wolf-Dieter Heiss (MPG: Max Planck Society)H-Index: 93
view all 4 authors...
Radiology is strongly depending on medical imaging technology and consequently directing technological progress. A novel technology can only be established, however, if improved diagnostic accuracy influence on therapeutic management and/or overall reduced cost can be evidenced. It has been demonstrated recently that Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) can technologically be integrated into one single hybrid system. Some scientific arguments on the benefits ar...
107 CitationsSource
#1Eric C. Ford (Johns Hopkins University)H-Index: 45
#2Joseph M. Herman (Johns Hopkins University)H-Index: 59
Last. Richard L. Wahl (Johns Hopkins University)H-Index: 93
view all 4 authors...
Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18 F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18 F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and nec...
175 CitationsSource
#1Adam M. Alessio (UW: University of Washington)H-Index: 29
#2Paul E. Kinahan (UW: University of Washington)H-Index: 58
Last. Marguerite T. Parisi (Boston Children's Hospital)H-Index: 13
view all 6 authors...
Adult PET/CT acquisition protocols need to be modified for pediatric imaging to minimize the radiation dose while maintaining diagnostic utility. We developed pediatric PET/CT acquisition protocols customized to patient weight and estimated the dosimetry and cancer risk of these low-dose protocols to communicate basic imaging risks.Methods:Protocols were developed for whole-body 18 F-FDG imaging ofpatients in PET mode with a weight-based injected activity (5.3 MBq/kg) and acquisition times (3‐5 ...
107 CitationsSource
The use of PET/CT in children has grown substantially in the past few years. There is also an increased interest in keeping the radiation dose to children from CT as low as is clinically practical. This article reviews the physical aspects of both PET and CT separately and how CT is used in the context of PET/CT to provide the practical insight necessary to approach this issue. Understanding radiation dosimetry and its potential for deleterious health effects, having knowledge of the magnitude o...
83 CitationsSource
#1Dan J. Kadrmas (UofU: University of Utah)H-Index: 23
#2Michael E. Casey (Siemens)H-Index: 41
Last. David W. Townsend (UT: University of Tennessee)H-Index: 60
view all 6 authors...
The PET components in the most recent generation of combined PET/CT scanners are equipped with time-of-flight (TOF) capability. The premise for TOF PET is illustrated in Figure 1, which also shows the point spread function (PSF) for 2 source positions. When a PET radioisotope decays, it emits a positron that annihilates with a nearby electron, giving rise to a pair of 511-keV photons emitted simultaneously in (nearly) opposite directions. If both these photons interact with and are detected by t...
250 CitationsSource
#1Bo Zhao (University of Pittsburgh)H-Index: 14
#2Yong Yang (University of Pittsburgh)H-Index: 9
Last. M. Saiful Huq (University of Pittsburgh)H-Index: 27
view all 6 authors...
In stereotactic body radiotherapy(SBRT), the respiratory tumor motion makes target definition very important to achieve optimal clinical results for treatment of early stage lungcancer. In this article, the authors quantitatively evaluated the influence of different target definition strategies on image-guided respiratory-gated SBRT for lungcancer. Twelve lungcancer patients with 4D CT estimated target motion of > 1 cm were selected for this retrospective study. An experienced physician contoure...
21 CitationsSource
#1Yoko MasudaH-Index: 3
#2Chisato KondoH-Index: 15
Last. Kiyoko KusakabeH-Index: 10
view all 5 authors...
The quality of 18 F-FDG PET/CT images of overweight patients is often degraded. We evaluated the effect of optimizing injected dose or acquisition time on the quality of images of overweight patients using lutetium oxyorthosilicate PET/CT with high-performance detector electronics. Methods: We initially retrospectively measured radioactivity concentrations and signal-to-noise ratios (SNRs) in the liver relative to body weight for 80 patients who had undergone 18F-FDG PET/CT according to our stan...
112 CitationsSource
#1Thorsten D. PoeppelH-Index: 26
#2Bernd J. Krause (TUM: Technische Universität München)H-Index: 45
Last. Gerald AntochH-Index: 51
view all 6 authors...
Abstract Positron emission tomography (PET) and computed tomography (CT) complement each other's strengths in integrated PET/CT. PET is a highly sensitive modality to depict the whole-body distribution of positron-emitting biomarkers indicating tumour metabolic activity. However, conventional PET imaging is lacking detailed anatomical information to precisely localise pathologic findings. CT imaging can readily provide the required morphological data. Thus, integrated PET/CT represents an effici...
222 CitationsSource
#1Richard L. Wahl (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 93
#2Heather A. Jacene (Johns Hopkins University)H-Index: 26
Last. Martin A. Lodge (Johns Hopkins University)H-Index: 29
view all 4 authors...
The purpose of this article is to review the status and limitations of anatomic tumor response metrics including the World Health Organization (WHO) criteria, the Response Evaluation Criteria in Solid Tumors (RECIST), and RECIST 1.1. This article also reviews qualitative and quantitative approaches to metabolic tumor response assessment with 18 F-FDG PET and proposes a draft framework for PET Response Criteria in Solid Tumors (PERCIST), version 1.0. Methods: PubMed searches, including searches f...
2,747 CitationsSource
Cited By29
Newest
#1Justin G. PeacockH-Index: 7
#2Chad T ChristensenH-Index: 2
Last. Kevin P. Banks (USU: Uniformed Services University of the Health Sciences)H-Index: 7
view all 3 authors...
SUMMARY: Tumor response assessments are essential to evaluate cancer treatment efficacy and prognosticate survival in patients with cancer. Response criteria have evolved over multiple decades, including many imaging modalities and measurement schema. Advances in FDG-PET/CT have led to tumor response criteria that harness the power of metabolic imaging. Qualitative PET/CT assessment schema are easy to apply clinically, are reproducible, and yield good prognostic results. We present 3 such criter...
2 CitationsSource
#1Lingyang Hua (Fudan University)H-Index: 6
#2Fengchun Hua (Fudan University)H-Index: 1
Last. Ye Gong (Fudan University)H-Index: 9
view all 10 authors...
Objective: This study aims to evaluate the potential role of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in detecting high-grade meningiomas and predicting the prognosis of patients after meningioma surgery. Patients and methods: A total of 124 patients met the final inclusion criterion. Tumor to gray ratio (TGR) was compared with Ki-67 labeling index, and its correlations with pre-operative neurological function and treatment status were also evaluated. Receiver-operating ...
1 CitationsSource
#1Quoc-Bao D. Nguyen (University of Texas Health Science Center at Houston)H-Index: 2
#2Robert J. Amato (University of Texas Health Science Center at Houston)H-Index: 31
Last. Yoshua Esquenazi (University of Texas Health Science Center at Houston)H-Index: 15
view all 7 authors...
Background Meningiomas are the most common primary intracranial tumors. The current diagnosis and treatment of meningioma is dependent on computed tomography and magnetic resonance imaging, with follow-up management relying mainly on magnetic resonance imaging. The limitations of these structural imaging modalities include delineation of the tumor extent, tumor grade, and differentiation from other meningioma mimickers, especially in or around the skull base. Because studies with positron emissi...
2 CitationsSource
#1Mengting Li (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Yichun Wang (HUST: Huazhong University of Science and Technology)H-Index: 5
Last. Xiaoli Lan (HUST: Huazhong University of Science and Technology)H-Index: 16
view all 4 authors...
: Molecular imaging has played an important role in the noninvasive exploration of multiple biological processes. Reporter gene imaging is a key part of molecular imaging. By combining with a reporter probe, a reporter protein can induce the accumulation of specific signals that are detectable by an imaging device to provide indirect information of reporter gene expression in living subjects. There are many types of reporter genes and each corresponding imaging technique has its own advantages a...
17 CitationsSource
#1Norbert GalldiksH-Index: 38
#2Nathalie L. Albert (LMU: Ludwig Maximilian University of Munich)H-Index: 20
Last. Jörg C. Tonn (LMU: Ludwig Maximilian University of Munich)H-Index: 37
view all 14 authors...
Meningiomas are the most frequent nonglial primary brain tumors and represent about 30% of brain tumors. Usually, diagnosis and treatment planning are based on neuroimaging using mainly MRI or, rarely, CT. Most common treatment options are neurosurgical resection and radiotherapy (eg, radiosurgery, external fractionated radiotherapy). For follow-up after treatment, a structural imaging technique such as MRI or CT is used. However, these structural imaging modalities have limitations, particularl...
60 CitationsSource
#1Matthew D. Galbraith (Anschutz Medical Campus)H-Index: 17
#2Zdenek Andrysik (Anschutz Medical Campus)H-Index: 14
Last. Joaquín M. Espinosa (Anschutz Medical Campus)H-Index: 35
view all 8 authors...
Summary Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report here an analysis of colorectal cancer cells engineered to carry a single point mutation in the active site of the Mediator-associated kinase CDK8, creating hypomorphic alleles sensitive to bulky ATP analogs. Transcriptome analysis revealed that CDK8 kina...
37 CitationsSource
#1Dan Shao (Academy of Medical Sciences, United Kingdom)H-Index: 3
#2Qiang GaoH-Index: 3
Last. Shu-xia Wang (Guangdong General Hospital)
view all 6 authors...
Abstract Objectives The purpose of this study was to evaluate the differential diagnostic value of 18 F-fluorodeoxy glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) for benign and malignant testicular lesions. Methods The PET/CT scans of 53 patients with testicular lesions confirmed by biopsy or surgical pathology were retrospectively analyzed. There were 32 cases of malignant tumors and 21 cases of benign lesions. Differences in the maximum standardized uptake value (...
5 CitationsSource
#1D. Berwouts (Ghent University Hospital)H-Index: 10
#2Katrien De Wolf (Ghent University Hospital)H-Index: 6
Last. Piet Ost (Ghent University Hospital)H-Index: 36
view all 9 authors...
Introduction To report the impact on target volume delineation and dose to normal tissue using anatomic versus biological imaging (18F-FDG-PET) for bone metastases. Methods Patients with uncomplicated painful bone metastases were randomized (1:1:1) and blinded to receive either 8 Gy in a single fraction with conventionally planned radiotherapy (ConvRT-8 Gy) or 8 Gy in a single fraction with dose-painting-by-numbers (DPBN) dose range between 6 and 10 Gy) (DPBN-8 Gy) or 16 Gy in a single fraction ...
1 CitationsSource
#1Sara Sheikhbahaei (Johns Hopkins University)H-Index: 29
#2Esther Mena (Johns Hopkins University)H-Index: 22
Last. Rathan M. SubramaniamH-Index: 35
view all 6 authors...
: A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and these allow more accurate therapy response assessment and survival prognostication. Multiple studies have addressed the utility of the volumetric PET biomarkers as prognostic indicators but there is no consensus about the preferred segmentation m...
7 CitationsSource
#1Zhiwei Zhang (Dalian Medical University)H-Index: 10
#2Zheng Zhu (Dalian Medical University)H-Index: 3
Last. Xishuang Song (Dalian Medical University)H-Index: 13
view all 9 authors...
In recent years, study concerning activity inhibitors of prostate-specific membrane antigen (PSMA) has been concentrated on the glutamic urea (Glu-urea-R) small molecule and its analogs. The present study aimed to synthesize 4 analogs of Glu-urea-R and identify the affinities of these compounds to PSMA. The compounds were synthesized from raw materials, and the experimental procedures of the present study were in accordance with standard techniques under anhydrous and anaerobic conditions. Glu-u...
2 CitationsSource