Endothelial Progenitor Cells and the Diabetic Paradox Current Knowledge and Therapeutic Perspectives

The discovery of postnatal vasculogenesis and of the important roles played by bone marrow-derived Endothelial Progenitor Cells was a landmark in vascular biology that forever has changed the concept of neovascularization. Diabetes associated vascular complications involve distinct modifications in neovascular formation, which is reduced in cardiovascular disease and increased in diabetic retinopathy, defining the diabetic paradox. The...