Original paper
The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
Abstract
ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich) domain using engineered glycans, sequence swaps, and single point mutations in this domain. Mutagenesis of Cys-rich...
Paper Details
Title
The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
Published Date
Mar 19, 2015
Journal
Volume
125
Issue
12
Pages
1968 - 1975
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Notes
History