Peptide-based Biopolymers in Biomedicine and Biotechnology

Published on Sep 1, 2008in Materials Science & Engineering R-reports
· DOI :10.1016/J.MSER.2008.04.004
Dominic C. Chow9
Estimated H-index: 9
(Duke University),
Michelle L. Nunalee2
Estimated H-index: 2
(Duke University)
+ 2 AuthorsAshutosh Chilkoti103
Estimated H-index: 103
(Duke University)
Sources
Abstract
Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers, and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.
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