Michelle L. Nunalee
Duke University
MicelleSelectivityBiophysicsProtein engineeringPeptide sequenceNanotechnologyChemistryMaterials scienceHydrodynamic radiusBiomaterialBiopolymerPeptideDrug deliveryCalmodulinBiomoleculeTissue engineeringCalciumBiochemistryDivalentProtein purification
Publications 2
#1Wafa Hassouneh (Duke University)H-Index: 10
Last. Ashutosh ChilkotiH-Index: 103
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Calcium-sensitive elastin-like polypeptides (CELPs) were synthesized by periodically interspersing a calcium-binding peptide sequence from calmodulin within an elastin-like polypeptide (ELP) with the goal of creating thermal and calcium responsive peptide polymers. The CELPs exhibit high sensitivity to calcium compared to monovalent cations but do not exhibit the exquisite selectivity for calcium over other divalent cations, such as magnesium, that is displayed by calmodulin. The CELPs were furt...
15 CitationsSource
#1Dominic C. Chow (Duke University)H-Index: 9
#2Michelle L. Nunalee (Duke University)H-Index: 2
Last. Ashutosh Chilkoti (Duke University)H-Index: 103
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Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers,...
291 CitationsSource