CFTR and Cationic Trypsinogen Mutations in Idiopathic Pancreatitis and Neonatal Hypertrypsinemia

The CFTR gene has been shown to be involved in sporadic idiopathic pancreatitis (IP) and neonatal hypertrypsinemia with normal sweat chloride test (NHNST). The cationic trypsinogen gene (Try4) is responsible for hereditary pancreatitis. The aim of the present study was to find a correlation between mutations in the two genes and the two phenotypes.Analysis of some known gene mutations and complete gene screening by denaturing gradient gel...