Last. Miklós Sahin-Tóth(UCLA: University of California, Los Angeles)H-Index: 55
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Abstract null null The calcium-sensing receptor (CASR) is expressed in the pancreas where it might regulate calcium concentrations in pancreatic secretions. Two independent studies reported conflicting results claiming that commonly occurring missense variants of the CASR gene are risk factors for chronic pancreatitis (CP). Here, we attempted to replicate the association between CASR variants and CP. We analyzed 337 patients and 840 controls from the Hungarian National Pancreas Registry either b...
Abstract null null Background/objectives null This study aimed to develop the prognostic score (PS) based on clinical factors to stratify the prognosis in borderline resectable pancreatic cancer (BRPC) patients treated with neoadjuvant therapy (NAT). null null null Methods null This retrospective study included 57 BRPC patients who received NAT between April 2012 and December 2017. A score was assigned to each prognostic factor available before and after NAT, according to their β coefficients. n...
Abstract null null Background null The clinical value and predictors of a favorable histological response to preoperative chemoradiotherapy (CRT) in pancreatic ductal adenocarcinoma (PDAC) remains undefined. null null null Objective null To assess the significance and predictors of a favorable histological response to preoperative CRT in patients with localized PDAC. null null null Methods null The study included 203 patients with localized PDAC undergoing curative-intent resection after CRT. Th...
#1Maren Ewers(TUM: Technische Universität München)H-Index: 4
#2Lucie Canaff(MUHC: McGill University Health Centre)H-Index: 34
Last. Jonas Rosendahl(MLU: Martin Luther University of Halle-Wittenberg)H-Index: 9
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Abstract null null Background null The calcium sensing receptor (CASR) is a G protein-coupled receptor that is responsible for assessing extracellular Ca2+ levels and thus plays a crucial role in calcium homeostasis. Hypercalcemia is a metabolic risk factor for pancreatitis and rare CASR variants have been described in patients with chronic pancreatitis. At the carboxy-terminal tail of CASR, there is a cluster of three common polymorphisms, p.A986S (rs1801725), p.R990G (rs1042636) and p.Q1011E (...
#1Yi Tat Tong(University of Texas MD Anderson Cancer Center)
#2Hua Wang(University of Texas MD Anderson Cancer Center)H-Index: 48
Last. Robert A. Wolff(University of Texas MD Anderson Cancer Center)H-Index: 91
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Abstract null null Background null Glucose-regulated protein 78 (GRP78) plays an essential role in protein folding, transportation, and degradation, thus regulates ER homeostasis and promotes cell survival, proliferation and invasion. GRP78 expression in PDAC patients who received neoadjuvant therapy has not been reported. null null null Methods null This retrospective study of resected PDAC patients included 125 patients treated with neoadjuvant therapy (NAT) and 140 patients treated with surge...
Last. Myung-Hwan Kim(UOU: University of Ulsan)H-Index: 89
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Abstract null null Background null Retroperitoneal neurogenic tumors are extremely rare pathological entities; therefore, few clinical features and natural courses, especially originating from the pancreatic/peripancreatic regions, have been reported. This study aimed to investigate the clinicopathological features of pancreatic and peripancreatic neurogenic tumors and assess the diagnostic value of computed tomography (CT) and endoscopic ultrasound-guided fine needle biopsy (EUS-FNB). null null...
Last. J. Rhee(Royal Australian College of General Practitioners)
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Abstract null null Background/objectives null Diagnosis of pancreatic cancer is often delayed, contributing to patient and family distress and leading to worse survival. We aimed to develop a decision support tool to support primary care providers to identify patients that should undergo investigations for pancreatic cancer, and to recommend initial diagnostic pathways. null null null Methods null A modified Delphi process, including a series of three surveys, was undertaken to ascertain clinica...
Abstract null null Background & aims null Increased intrapancreatic fat is associated with pancreatic diseases; however, there are no established objective diagnostic criteria for fatty pancreas. On non-contrast computed tomography (CT), adipose tissue shows negative Hounsfield Unit (HU) attenuations (−150 to −30 HU). Using whole organ segmentation on non-contrast CT, we aimed to describe whole gland pancreatic attenuation and establish 5th and 10th percentile thresholds across a spectrum of age...
Abstract null null Background null The aim of this study was to investigate the clinical value of nutritional and immunological prognostic scores as predictors of outcomes and to identify the most promising scoring system for patients with pancreatic ductal adenocarcinoma (PDAC) in a multi-institutional study. null null null Methods null Data were retrospectively collected for 589 patients who underwent surgical resection for PDAC. Prognostic analyses were performed for overall (OS) and recurren...
BACKGROUND/OBJECTIVES Resections for intraductal papillary mucinous neoplasm (IPMN) have increased last decades. Overall survival (OS) for conventional pancreatic ductal adenocarcinoma (PDAC) is well known but OS for invasive IPMN (inv-IPMN) is not as conclusive. This study aims to elucidate potential differences in clinicopathology and OS between these tumor types and to investigate if the raised number of resections have affected outcome. METHODS Consecutive patients ≥18 years of age resected ...