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Original paper

Claudin-4 expression is associated with tumor invasion, MMP-2 and MMP-9 expression in gastric cancer

Volume: 1, Issue: 5, Pages: 789 - 797
Published: Jan 1, 2010
Abstract
Claudin-4 is a member of the claudin family, a large family of transmembrane proteins that are essential in the formation and maintenance of tight junctions. Matrix metal-loproteinase (MMP)-2 and -9 degrade type IV collagen of the extracellular matrix and basal membranes. Claudin-4 activates MMP-2, indicating that claudin-mediated increased cancer cell invasion may result from the activation of MMP proteins. In the present study, we used...
Paper Details
Title
Claudin-4 expression is associated with tumor invasion, MMP-2 and MMP-9 expression in gastric cancer
Published Date
Jan 1, 2010
Volume
1
Issue
5
Pages
789 - 797
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