Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro
Abstract
Icariin, a principal flavonoid glycoside in Herba Epimedii, is hypothesized to possess beneficial effects on bone mass. Icariin is metabolized to icariside II and then to icaritin in vivo. In the present study, we investigated the in vitro effects of icariin, icariside II and icaritin on both osteoblasts and osteoclasts. After treatment with these compounds at concentrations 10− 5–10− 8 mol/l, osteoblasts were examined for proliferation,...
Paper Details
Title
Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro
Published Date
Aug 1, 2007
Journal
Volume
81
Issue
10
Pages
832 - 840
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