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Abstract null null Aims null Since our troops had returned from the first Persian Gulf War in 1990–91, the veterans have reported chronic multisymptomatic illness widely referred to as Gulf War Illness (GWI). We aim to review the current directions of GWI pathology research in the context of chronic multisymptomatic illness and its possible gut microbiome targeted therapies. The veterans of Gulf War show symptoms of chronic fatigue, cognitive deficits, and a subsection report of gastrointestinal...
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Abstract null null Aims null Intestinal nutrient absorption plays a vital role in developing obesity, and nutrient transporters expressed in the enterocytes facilitate this process. Moreover, previous studies have shown that specific foods and diets can affect their cell levels. Herein, we investigated the effects of pequi oil (PO), which is high in several bioactive compounds, on intestinal nutrient transporter levels as well as on intestinal morphology and metabolic biomarkers. null null null ...
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#1Eduardo Souza-Silva (UFSC: Universidade Federal de Santa Catarina)H-Index: 4
#2Ruy Ascenso (UFSC: Universidade Federal de Santa Catarina)
Last. José Eduardo da Silva-Santos (UFSC: Universidade Federal de Santa Catarina)H-Index: 17
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Abstract Aims Post-occlusive reactive hyperemia (PORH) remains poorly understood in the skeletal muscle system. This study was designed to validate an alternative strategy of PORH detection in rodents. Additionally, we explored the hypothesis that PORH is influenced by experimental models associated with impaired function of the skeletal muscle. Materials and methods Wistar rats were anesthetized, and blood flow was assessed by laser Doppler in the anterior tibialis muscle, before and immediatel...
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#1Kunal Dixit (Symbiosis International University)
#2Diptaraj Chaudhari (National Center for Charitable Statistics)
Last. Sunil D Saroj (Symbiosis International University)H-Index: 1
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Abstract The human microbiome is a complex and dynamic ecosystem, and the imbalance of its microbial community structure from the normal state is termed dysbiosis. The dysbiotic gut microbiome has been proved to be related to several pathological conditions like Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), Colorectal Cancer (CRC), etc., and several other extra-intestinal conditions like Type 1 & 2 diabetes, obesity, etc. The complex gut microbial ecosystem starts to build be...
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#1Maiara Mikuska Cordeiro (Ponta Grossa State University)H-Index: 3
#2Patrícia Bubna Biscaia (Ponta Grossa State University)
Last. Dionizia Xavier Scomparin (Ponta Grossa State University)H-Index: 10
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Abstract Aims Vitamin (Vit) D regulates various organic processes, including adipose tissue morphofunction and lipid metabolism. Studies indicate that Vit D bioavailability is reduced in obesity, which could contribute to obesity development; however, the effects of Vit D supplementation on increased adiposity in western diet (WD)-obese rats (an experimental model that better resembles the obesogenic human obesity condition) have not been studied, to date. Thus, we hypothesized that Vit D supple...
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#1Dhananjay Kumar Sah (DU: University of Delhi)H-Index: 1
#2Yogesh Rai (DRDO: Defence Research and Development Organisation)H-Index: 4
Last. Anant Narayan Bhatt (DRDO: Defence Research and Development Organisation)H-Index: 16
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Abstract Exposure to ionizing radiation (IR) set a series of deleterious events causing acute radiation syndrome and mortality, posing the need for a potent and safe radio-protective drug. IR induces cell death predominantly by causing oxidative stress and macromolecular damage. The pre-existing antioxidant defence machinery of the cellular system plays a crucial role in protecting the cells against oxidative stress by activation of Nrf2. The current study was undertaken to investigate the radio...
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#1Yi Wang (NKU: Nankai University)
#2Shengwen Wang (NKU: Nankai University)
Last. Chunhua Liu (NKU: Nankai University)
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Abstract Studies reported that sodium hydrosulfide (NaHS) can remit the depressive-like and anxiety-like behaviors induced by type 1 diabetes mellitus (T1DM). However, the mechanism is still unclear. In this study, we aimed to investigate the mechanism of NaHS on T1DM. Mice were randomly divided into four groups, including the control group (CON group), DM group, DM + 5.6 mg/kg NaHS group, and CON + 5.6 mg/kg NaHS group. Data showed that NaHS did attenuate the depressive-like and anxiety-like be...
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#1Behrouz Foroughi-nia (Tabriz University of Medical Sciences)H-Index: 1
#2Jaleh Barar (Tabriz University of Medical Sciences)H-Index: 38
Last. Soudabeh Davaran (Tabriz University of Medical Sciences)H-Index: 4
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Tyrosine kinase inhibitors (TKIs), as an important class of chemotherapeutic drugs, induce apoptosis by altering the path of the cellular signal, resulting in cell death. However, some chemotherapeutic drugs have a limited therapeutic index and are usually destructive as well as unpredictable. In addition, the limitation of early diagnosis and inefficiency of some of the drugs in ordinary treatments lead to disease progression and decreases in the survival of cancer patients. For this purpose, v...
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#1Heba A. Habib (Minia University)H-Index: 1
#2Gehan H. Heeba (Minia University)H-Index: 16
Last. Mohamed M.A. Khalifa (Minia University)H-Index: 9
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Abstract Aims Diabetic nephropathy, a major threat to diabetic patients, is considered as the main reason for end-stage renal disease. Fortunately, incretin-based therapy has been aroused as considerable source to attenuate diabetic renal damage. This study aimed to investigate whether superior protective effects on the progression of diabetic kidney are exerted by glucagon-like peptide-1 analog, exenatide, or dipeptidyl peptidase-4 inhibitor, sitagliptin. Materials and methods Male Wistar rats ...
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#1Adel T. Osman (Al-Azhar University)H-Index: 1
#2Souty M.Z. Sharkawi (Beni-Suef University)H-Index: 4
Last. Ramadan A.M. Hemeida (Al-Azhar University)H-Index: 11
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Abstract Hepatotoxicity is the main adverse effect of methotrexate (MTX), which limits its clinical use and effectiveness. Both empagliflozin (EMPA) and neohesperidin dihydrochalcone (NHD) have promising criteria for suppressing oxidative stress, inflammation and apoptosis. In this current study, we suggested that EMPA and NHD exhibit protective effects against MTX-triggered liver injury, considering N-acetylcysteine (NAC) as a reference standard. In order to inspect our suggestion, An experimen...
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