Life Sciences
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#1Aline Pedro de Melo Yamamoto (UNESP: São Paulo State University)H-Index: 1
#2Fernando Yamamoto Chiba (UNESP: São Paulo State University)H-Index: 12
Last. BE Belardi (UNESP: São Paulo State University)H-Index: 3
view all 14 authors...
Abstract null null Aims null To investigate the effect of resistance training-RT on glycemia, expression of the glucose transporter-GLUT4, bone mineral density-BMD, and microstructural and biomechanical properties of osteopenic rat bones in neonatal streptozotocin-induced diabetes. null null null Main methods null Sixty-four 5-day-old male rats were divided into two groups: control and diabetic rats injected with vehicle or streptozotocin, respectively. After 55 days, densitometric analysis-DA o...
#1Runbao Du (Jilin University)H-Index: 1
#2Qianghua Lv (Jilin University)H-Index: 3
Last. Jianfeng Wang (Jilin University)H-Index: 25
view all 10 authors...
Abstract null null Aims null The spread of plasmid-mediated polymyxin resistance has jeopardized the use of polymyxin, the last defender that combats infections caused by multidrug-resistant (MDR) gram-negative pathogens. null null null Main methods null In this study, phloretin, as a monomeric compound extracted from natural plants, showed a good synergistic effect with polymyxin E against gram-negative bacteria, as evaluated by minimal inhibit concentration (MIC) assay and a series of assays, ...
#1Kishore Banik (IITG: Indian Institute of Technology Guwahati)H-Index: 23
#2Elina Khatoon (IITG: Indian Institute of Technology Guwahati)H-Index: 8
Last. Ajaikumar B. Kunnumakkara (IITG: Indian Institute of Technology Guwahati)H-Index: 63
view all 7 authors...
Abstract null null Background null Chronic diseases or non-communicable diseases are a major burden worldwide due to the lack of highly efficacious treatment modalities and the serious side effects associated with the available therapies. null null null Purpose/study design null A novel self-emulsifying formulation of curcumin with fenugreek galactomannan hydrogel scaffold as a water-dispersible non-covalent curcumin-galactomannan molecular complex (curcumagalactomannosides, CGM) has shown bette...
#1Xudong Ma (ZJUT: Zhejiang University of Technology)H-Index: 2
#2Annoor Awadasseid (ZJUT: Zhejiang University of Technology)H-Index: 8
Last. Wen Zhang (ZJUT: Zhejiang University of Technology)H-Index: 17
view all 8 authors...
Abstract null null Aims null This study aimed to evaluate the ability of compound 13d to induce autophagy and to promote apoptosis of tumor cells and its interaction mechanism. null null null Materials and methods null Using CCK-8 assay, transwell assay, fluorescence resonance energy transfer melting analysis (FRET), transmission electron microscopy, flow cytometry assay, immunofluorescence assay, Western blot analysis, and wound healing assay. null null null Key findings null The results indica...
#1Pariya Khodabakhsh (SBMU: Shahid Beheshti University of Medical Sciences)H-Index: 2
#2Maryam Bazrgar (SBMU: Shahid Beheshti University of Medical Sciences)
Last. Abolhassan Ahmadiani (SBMU: Shahid Beheshti University of Medical Sciences)H-Index: 33
view all 7 authors...
Abstract null null Over the last decades, our knowledge of the key pathogenic mechanisms of Alzheimer's disease (AD) has dramatically improved. Regarding the limitation of current therapeutic strategies for the treatment of multifactorial diseases, such as AD, to be translated into the clinic, there is a growing trend in research to identify risk factors associated with the onset and progression of AD. Here, we review the current literature with a focus on the relationship between gastrointestin...
#1Marwa M. Safar (BUE: British University in Egypt)H-Index: 15
#2Noha F. Abdelkader (Cairo University)H-Index: 13
Last. Ahmed F. Mohamed (Cairo University)H-Index: 6
view all 5 authors...
Abstract null null Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs people's lives tremendously. The development of innovative treatment modalities for PD is a significant unmet medical need. The critical function of glucagon-like peptide-1 (GLP-1) in neurodegenerative diseases has raised impetus in investigating the repositioning of a dipeptidyl peptidase IV inhibitor, alogliptin (ALO), as an effective treatment for PD. As a result, the focus of this research was...
#1Mariángeles Díaz (UBA: University of Buenos Aires)H-Index: 7
#2Matías Pibuel (UBA: University of Buenos Aires)H-Index: 5
Last. Silvina Lompardía (UBA: University of Buenos Aires)H-Index: 7
view all 8 authors...
Abstract null null Aims null Despite continuous improvement in the treatment of acute leukemia, new therapies are still needed to overcome resistance and reduce adverse effects. The aim of this work was to study the tumor-suppressive effects of 4-methylumbelliferone (4MU) in human acute leukemia cell lines. In addition, we aimed to address the extent of these effects in relation to the inhibition of hyaluronic acid (HA) synthesis. null null null Main methods null HA levels were measured by an EL...
#1Michael D. Wiese (University of South Australia)H-Index: 30
#2Ashley S. Meakin (University of South Australia)
Last. Janna L. Morrison (University of South Australia)H-Index: 43
view all 9 authors...
Abstract null null Introduction null Non-alcoholic fatty liver disease (NAFLD) is characterised by accumulation of triglycerides and cholesterol within the liver and dysregulation of specific hepatic cytochrome P450 (CYPs) activity. CYPs are involved in the metabolism of endogenous and exogenous chemicals. Hepatic CYP activity is dysregulated in human studies and animal models of a Western diet (WD) or low birth weight (LBW) independently, but the additive effects of LBW and postnatal WD consump...
#1Eloisa Sanches Pereira do Nascimento (UnB: University of Brasília)H-Index: 3
#2Walter Moreno Campos Nunes (UnB: University of Brasília)
Last. Verônica Amado (UnB: University of Brasília)H-Index: 9
view all 11 authors...
Abstract null null Aim null Physical exercise training attenuates pulmonary inflammation, but its effects on impaired respiratory function caused by hepatopulmonary syndrome (HPS) have not been evaluated. We determined if the combination of moderate intensity aerobic and resistance training during HPS development modifies exercise capacity, respiratory system mechanics, and lung inflammation responses. null null null Main methods null Wistar rats were randomly divided into sham, HPS, and HPS + c...
#1Ralmony de Alcantara Santos (UNIFESP: Federal University of São Paulo)H-Index: 4
#2Vinicius Guzzoni (UNIFESP: Federal University of São Paulo)
Last. Tatiana Sousa Cunha (UNIFESP: Federal University of São Paulo)H-Index: 15
view all 10 authors...
Abstract null null Aims null We aimed to determine whether resistance training (RT) regulates renal renin-angiotensin system (RAS) components and inflammatory mediators in diabetic rats. null null null Main methods null Male Wistar rats (3 months old) were randomly assigned into four groups: non-trained (NT), trained (T), non-trained + diabetes (NTD) and trained +diabetes (TD). Diabetes was induced by streptozotocin (50 mg/kg, Sigma Chemical Co., St. Louis, MO, USA), before RT protocol. Trained ...
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