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#1Navneet Joshi (Mody University of Science & Technology)H-Index: 1
#2Farnaz Hajizadeh (Tabriz University of Medical Sciences)H-Index: 3
Last. Farhad Jadidi-Niaragh (Tabriz University of Medical Sciences)H-Index: 34
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Abstract Aims Despite extensive efforts to find new treatments, chemotherapy is still one of the first and foremost choices for cancer treatment. The main problems of using these drugs are the resistance of cancer cells and reducing their sensitivity to chemotherapy as well as the side effects of their systemic administration. Because STAT3 plays a very important role in the survival and susceptibility of cancer cells to apoptosis, we hypothesized that suppression of STAT3 expression could induc...
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#1Danielle Paige Anthony (Manipal University)
#2Manasa Hegde (Manipal University)H-Index: 1
Last. B.S. Satish Rao (Manipal University)
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Abstract The blood-brain barrier (BBB) is composed of a layer of endothelial cells that is interspersed with a series of tight junctions and characterized by the absence of fenestrations. The permeability of this barrier is controlled by junctions such as tight junctions and adherent junctions as well as several cells such as astrocytes, pericytes, vascular endothelial cells, neurons, microglia, and efflux transporters with relatively enhanced expression. It plays a major role in maintaining hom...
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#1Elizabeth Dimbath (ECU: East Carolina University)
#2Veeranna Maddipati (ECU: East Carolina University)H-Index: 1
Last. Ali Vahdati (ECU: East Carolina University)H-Index: 2
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The COVID-19 pandemic surges on as vast research is produced to study the novel SARS-CoV-2 virus and the disease state it induces. Still, little is known about the impact of COVID-19-induced microscale damage in the lung on global lung dynamics. This review summarizes the key histological features of SARS-CoV-2 infected alveoli and links the findings to structural tissue changes and surfactant dysfunction affecting tissue mechanical behavior similar to changes seen in other lung injury. Along wi...
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#1Hesham Fathy Hassan Hassan (Al-Azhar University)H-Index: 1
#2Ahmed Mohamed Mansour (Al-Azhar University)H-Index: 3
Last. El-Sayed M. El-Sayed (Al-Azhar University)H-Index: 1
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Abstract Aim Evaluating the possible protective effect of thymol as an approach against 1,2 N,N-dimethylhydrazine and/or high-fat diet (HFD)-induced colon cancer. Main methods Adult male Wistar rats were divided into 7 groups, namely a normal control group, colon cancer groups received DMH (40 mg/kg i.p., twice weekly), 20% HFD and DMH/HFD, thymol (20 mg/kg/day, p.o.), thymol/DMH and thymol/DMH/HFD (treatment of all groups continued for 16 weeks). Key findings Thymol significantly reduced the el...
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Last. Guangwen Yin (Zhengzhou University)H-Index: 2
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#1Ya Fei Geng (Jiangnan University)
#2Cheng Yang (Jiangnan University)H-Index: 20
Last. Bing Tian Zhao (Jiangnan University)
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Abstract Aims The emergence of antibiotic tolerance was a tricky problem in the treatment of chronic Pseudomonas aeruginosa-infected cystic fibrosis and burn victims. The quorum sensing (QS) inhibitor may serve as a new tactic for the bacterial resistance by inhibiting the biofilm formation and the production of virulence factors. This study explored the potential of luteolin as a QS inhibitor against P. aeruginosa and the molecular mechanism involved. Main methods Crystal violet staining, CLSM ...
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#1Yanting Yuan (Qingdao University)H-Index: 1
#2Ji Zhou (Qingdao University)H-Index: 1
Last. Guohui Jiang (Qingdao University)H-Index: 5
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Abstract Aims Piperine, the major pharmacological ingredient of pepper, can delay the procession of “obesity to diabetes”. However, the underlying mechanism remains unclear. This study aims to investigate whether piperine protects against β-cell dysfunction by inhibiting macrophage accumulation and M1-like polarization. Materials and methods Pre-diabetic model was induced by feeding 60% high-fat diet (HFD) in C57BL/6 mice, piperine (15 or 30 mg/kg/day) and rosiglitazone (4 mg/kg/day) were given ...
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#1Qiang Wang (Jiangsu University)H-Index: 6
#2Jing Wang (Jiangsu University)
Last. Heng Zhang (SEU: Southeast University)H-Index: 3
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Abstract Liver X receptors (LXRs) are receptors that belong to the nuclear receptor superfamily (NRs). It was originally called the “orphan receptor” when it was firstly discovered. Then it was found to be activated by oxysterol and it was officially named LXRs. LXRs are activated by ligands and bind to the retinol X receptor to form a heterodimer and regulate metabolism. Numerous studies have shown that LXRs are involved in regulating immune function and maintaining immune tolerance. Activating...
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#1Razieh Dalirfardouei (Hamedan University of Medical Sciences)
Last. Fahimeh Afzaljavan (MUMS: Mashhad University of Medical Sciences)H-Index: 4
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Abstract A growing body of evidence has shown that extracellular vesicles can be efficient as experimental therapeutics in pre-clinical models of skin wounds, but there is a significant unmet need to translate this to clinical utilization. The objectives of the current systematic review were to identify the strength of the therapeutic effects of EVs derived from stem cells in cutaneous wounds and to assess which EV-mediated mechanisms could be involved in the therapeutic response. PubMed, ISI We...
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#2Juan Wang (Soochow University (Suzhou))
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Abstract Aims Previous reports have found that STAT4 is involved in the epithelial-mesenchymal transition (EMT), thereby regulating the metastasis and invasion of ovarian cancer. However, the mechanisms underlying remain unclear. Main methods We first established hypoxia-induced in vivo and in vitro models. The expression levels of signal transducer and activator of transcription 4 (STAT4), the markers of EMT and microRNA-200a (miR-200a) were assessed by western blot and qRT-PCR analysis, respec...
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