A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence
Abstract
Restricted iron availability is a major obstacle to growth and survival of pathogenic bacteria during infection. In contrast to Gram-negative pathogens, little is known about how Gram-positive pathogens obtain this essential metal. We have identified two Streptococcus pneumoniae genetic loci, pit1 and pit2, encoding homologues of ABC iron transporters that are required for iron uptake by this organism. S. pneumoniae strains containing disrupted...
Paper Details
Title
A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence
Published Date
May 1, 2001
Journal
Volume
40
Issue
3
Pages
572 - 585
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