Original paper
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
Volume: 50, Issue: 10, Pages: 1241 - 1252
Published: May 15, 2015
Abstract
Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-trophic effects and inhibition of pain sensation. To evaluate GC-C signaling, we examined the regulation of GC-C (GUCY2C/Gucy2c) and its endogenous ligands guanylin (GN/GUCA2A/Guca2a) and uroguanylin (UGN/GUCA2B/Guca2b) in colonic Crohn's disease (CD), ulcerative colitis...
Paper Details
Title
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
Published Date
May 15, 2015
Volume
50
Issue
10
Pages
1241 - 1252
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Notes
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