Bjorn I. Gustafsson
Norwegian University of Science and Technology
Internal medicineEndocrinologyPathologyCellReceptorChemistryImmunologySerotoninSomatostatinInflammatory bowel diseaseNeuroendocrine tumorsIntestinal mucosaSecretionCancer research5-HT receptorMedicineBiologyEnterochromaffin cellGastroenterologyCell biology
74Publications
27H-index
2,965Citations
Publications 73
Newest
#1Jonas Woll Jørandli (NTNU: Norwegian University of Science and Technology)H-Index: 1
#2Silje Thorsvik (NTNU: Norwegian University of Science and Technology)H-Index: 4
Last. Atle van Beelen Granlund (NTNU: Norwegian University of Science and Technology)H-Index: 13
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Serotonin is a highly conserved and ubiquitous signalling molecule involved in a vast variety of biological processes. Approximately 90% of serotonin is produced in the gastrointestinal tract, wher...
5 CitationsSource
#1Ann Elisabet Østvik (NTNU: Norwegian University of Science and Technology)H-Index: 9
#2Tarjei Dahl Svendsen (NTNU: Norwegian University of Science and Technology)H-Index: 2
Last. Torunn Bruland (NTNU: Norwegian University of Science and Technology)H-Index: 13
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BACKGROUND AND AIMS: Intestinal epithelial cells (IECs) secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease (IBD). However, experiments in patient-derived IEC models are still scarce. Here, we aimed to investigate how innate immunity and IEC-specific pattern recognition receptor (PRR) signaling can be involved in an enhanced type I interferon (IFN) gene signature observed in colon epithelium from patients w...
13 CitationsSource
#1Helge L. Waldum (NTNU: Norwegian University of Science and Technology)H-Index: 61
#2Kjell Öberg (Uppsala University)H-Index: 116
Last. Reidar Fossmark (NTNU: Norwegian University of Science and Technology)H-Index: 24
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Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is increasing evidence supporting an alternative paradigm. Tumours may develop by dedifferentiation from mature cells able to proliferate. Studies of gastric carcinogenesis demonstrate that mature neuroendocrine (NE) cells upon long-term overstimulation may develop through stages of ...
10 CitationsSource
Last. Torunn BrulandH-Index: 13
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#1Øystein BrennaH-Index: 5
#2Marianne W. Furnes (NTNU: Norwegian University of Science and Technology)H-Index: 9
Last. Bjorn I. GustafssonH-Index: 27
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Guanylin (GUCA2A/Guca2a/GN) and uroguanylin (GUCA2B/Guca2b/UGN) are expressed in the gastrointestinal tract and have been implicated in ion and fluid homeostasis, satiety, abdominal pain, growth and intestinal barrier integrity. Their cellular sources are debated and include goblet cells, entero-/colonocytes, enteroendocrine (EE) cells and tuft cells. We therefore investigated the cellular sources of GN and UGN mRNAs in human and rat duodenal and colonic epithelium with in situ hybridization (IS...
24 CitationsSource
#1Øystein Brenna (NTNU: Norwegian University of Science and Technology)H-Index: 5
#2Torunn Bruland (NTNU: Norwegian University of Science and Technology)H-Index: 13
Last. Bjorn I. Gustafsson (NTNU: Norwegian University of Science and Technology)H-Index: 27
view all 10 authors...
Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-trophic effects and inhibition of pain sensation. To evaluate GC-C signaling, we examined the regulation of GC-C (GUCY2C/Gucy2c) and its endogenous ligands guanylin (GN/GUCA2A/Guca2a) and uroguanylin (UGN/GUCA2B/Guca2b) in colonic Crohn’s disease (CD), ulcerative colitis (UC) and in rats with 2,4,6-Trinitrobenzen...
38 CitationsSource
#2Roswitha PfragnerH-Index: 22
Last. Bjorn I. GustafssonH-Index: 14
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2 Citations
#1Ann Elisabet Østvik (NTNU: Norwegian University of Science and Technology)H-Index: 9
#2Atle van Beelen Granlund (NTNU: Norwegian University of Science and Technology)H-Index: 13
Last. Arne K. Sandvik (NTNU: Norwegian University of Science and Technology)H-Index: 45
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BACKGROUND: Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA (CFB) potently upregulated and went on to further study localization of complement factor B synthesis and systemic activation of complement in ulcerative colitis and Crohn's disease. METHODS: In a transcriptome analysis of poly (I:C) stimulated HT-29 cells, we found CFB highly ...
18 CitationsSource
#1Øystein Sørdal (NTNU: Norwegian University of Science and Technology)H-Index: 10
#2Gunnar Qvigstad (NTNU: Norwegian University of Science and Technology)H-Index: 23
Last. Helge L. Waldum (NTNU: Norwegian University of Science and Technology)H-Index: 61
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Abstract Purpose The purpose of this study is to assess the exocrine and neuroendocrine properties of tumour cells in diffuse gastric cancer with signet ring cell differentiation. Material and methods Mucin mRNA and protein expressions (MUC1, 2, 3, 4, 5AC, 6 and MUC13) were assessed by immunohistochemistry and in situ hybridization. The neuroendocrine properties were evaluated by protein and mRNA expression of the general neuroendocrine markers chromogranin A and synaptophysin. Results No MUC ex...
19 CitationsSource
#1Øystein BrennaH-Index: 5
#2Marianne W. FurnesH-Index: 9
Last. Bjorn I. GustafssonH-Index: 27
view all 10 authors...
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