Diclofenac enhances allergic responses in a mouse peanut allergy model

Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) interfere with cyclo-oxygenase-mediated synthesis of prostaglandins, resulting in the inhibition of inflammatory immune responses. In contrast, it is known that NSAIDs are able to induce gastrointestinal damage.Our aim was to investigate whether NSAIDs are able to enhance sensitization or abrogate tolerance to food antigens.Mice were exposed to diclofenac and sensitized to...