Raymond Pieters
Utrecht University
Internal medicineEndocrinologyImmunoglobulin EAntigenCD8ChemistryIn vitroImmunologyIn vivoAllergyFood allergyT cellSensitizationInflammationPeanut allergyCytokineToxicityAllergic sensitizationMedicineBiologyImmune systemPharmacology
198Publications
36H-index
3,810Citations
Publications 199
Newest
#1Esther S. Lenssen (UU: Utrecht University)
#2Raymond Pieters (UU: Utrecht University)H-Index: 36
Last. Gerard Hoek (UU: Utrecht University)H-Index: 107
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BACKGROUND Epidemiological studies have associated biomass combustion with (respiratory) morbidity and mortality, primarily in indoor settings. Barbecuing results in high outdoor air pollution exposures, but the health effects are unknown. OBJECTIVE The objective was to investigate short-term changes in respiratory health in healthy adults, associated with exposure to barbecue fumes. METHODS 16 healthy, adult volunteers were exposed to barbecue smoke in outdoor air in rest during 1.5 h, using a ...
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#2M. Bol-Schoenmakers (UU: Utrecht University)H-Index: 14
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
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IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, both leading to IL22 production by T cells, but via different pathways. Bacterial products, such as LPS, induce enterocyte-secreted SAA1, which triggers the secretion of IL6 in fibroblasts, and s...
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The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells (ILCs) are found abundantly in the thoracic and peritoneal cavities, and they are crucial in first defense against pathogenic viruses and bacteria. Nanomaterials (NMs) can enter the cavities int...
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#1Raymond PietersH-Index: 36
#2Nienke BleijenbergH-Index: 13
Last. Harriet WittinkH-Index: 1
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#1Stefan C. DekkerH-Index: 35
#2Aletta D. KraneveldH-Index: 49
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The future of food is one of the major world-wide challenges. In this perspective paper, we set-up a framework for a multi-disciplinary future food systems approach, building on the UN Sustainable Development Goals. We hereby combine a truly sustainable approach including social science aspects combined with the One Health approach. Scientists from a large number of backgrounds have addressed four key areas that are discussed in more detail in this paper: (i) nature inspired food production, (ii...
1 CitationsSource
#1B.C.A.M. van Esch (UU: Utrecht University)H-Index: 16
#2J. van BilsenH-Index: 3
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Abstract Introduction This 4-center study is part of a project to validate a food allergy murine model for safety testing of hydrolyzed infant formulas. Aim The aim of the current multi-center experiment was to evaluate the residual allergenicity of three partial hydrolyzed whey proteins (pWH) in a multiple-parameter cow’s milk allergy murine model and to compare to the classically used guinea pig model. Previous work showed differences in the magnitude of the allergic response to whey between c...
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#2Klaske van Norren (WUR: Wageningen University and Research Centre)H-Index: 16
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
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Introduction Strenuous physical stress induces a range of physiological responses, the extent depending, among others, on the nature and severity of the exercise, a person's training level and overall physical resilience. This principle can also be used in an experimental set-up by measuring time-dependent changes in biomarkers for physiological processes. In a previous report, we described the effects of workload delivered on a bicycle ergometer on intestinal functionality. As a follow-up, we h...
1 CitationsSource
#1Giulio Giustarini (UU: Utrecht University)H-Index: 7
#2Suzanna Huppelschoten (LEI: Leiden University)H-Index: 3
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
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Abstract Idiosyncratic drug-induced liver injury (IDILI) is a severe disease that cannot be detected during drug development. It has been shown that hepatotoxicity of some compounds associated with IDILI becomes apparent when these are combined in vivo and in vitro with LPS or TNF. Among these compounds trovafloxacin (TVX) induced apoptosis in the liver and increased pro-inflammatory cytokines in mice exposed to LPS/TNF. The hepatocyte survival and the cytokine release after TNF/LPS stimulation ...
3 CitationsSource
#1Richard J. WeaverH-Index: 22
#2Eric A. G. BlommeH-Index: 14
Last. B. Kevin Park (University of Liverpool)H-Index: 93
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Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model systems for DILI prediction. This Perspective defines th...
40 CitationsSource
#1Clélia Villemin (INRA: Institut national de la recherche agronomique)H-Index: 3
#2Olivier Tranquet (INRA: Institut national de la recherche agronomique)H-Index: 14
Last. Grégory Bouchaud (INRA: Institut national de la recherche agronomique)H-Index: 15
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Gliadins are major wheat allergens. Their treatment by acid or enzymatic hydrolysis has been shown to modify their allergenic potential. As the interaction of food proteins with dendritic cells (DCs) is a key event in allergic sensitization, we wished to investigate whether deamidation and enzymatic hydrolysis influence gliadin processing by DC, and to examine the capacity of gliadins to activate DCs. We compared the uptake and degradation of native and modified gliadins by DCs using mouse bone ...
4 CitationsSource