Original paper
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Abstract
Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanisms, induce widespread inflammation. We found that a large proportion of primary spinal afferent neurons, which express proteinase-activated receptor 2, also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P. Trypsin and tryptase directly signal to neurons to stimulate release of these neuropeptides, which mediate...
Paper Details
Title
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Published Date
Feb 1, 2000
Journal
Volume
6
Issue
2
Pages
151 - 158
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Notes
History